PMID- 10407114
OWN - NLM
STAT- MEDLINE
DCOM- 19990910
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 834
IP  - 1-2
DP  - 1999 Jul 10
TI  - Induction of glial cell line-derived neurotrophic factor receptor proteins in
      cerebral cortex and striatum after permanent middle cerebral artery occlusion in 
      rats.
PG  - 190-5
AB  - In an attempt to elucidate whether glial cell line-derived neurotrophic factor
      (GDNF) receptors are induced after ischemic brain injury, possible expression of 
      immunoreactive GDNF receptor-alpha1 (GFRalpha-1) and c-ret (RET) was examined at 
      3, 8, or 24 h after permanent middle cerebral artery occlusion (MCAO) in rats.
      Immunohistochemical study showed that both GFRalpha-1 and RET staining cells
      which were not detected in sham control brain, were present in the ipsilateral
      cortex and caudate at 3 to 8 h after permanent MCAO, and then decreased but
      remained to some extent at 24 h. Positive cells for both GDNF receptors were
      predominantly in cortical neurons of ischemic penumbral area. Western blot
      analysis confirmed the induction of those receptors after permanent MCAO. This
      rapid induction of GFRalpha-1 and RET, which correlates with the similar
      induction of GDNF under these conditions, may play a role in the early response
      to ischemic brain injury.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Kitagawa, H
AU  - Kitagawa H
AD  - Department of Neurology, Okayama University Medical School, 2-5-1 Shikatacho,
      Okayama 700-8558, Japan. q_kitagawa@research.otsuka.co.jp
FAU - Sasaki, C
AU  - Sasaki C
FAU - Zhang, W R
AU  - Zhang WR
FAU - Sakai, K
AU  - Sakai K
FAU - Shiro, Y
AU  - Shiro Y
FAU - Warita, H
AU  - Warita H
FAU - Mitsumoto, Y
AU  - Mitsumoto Y
FAU - Mori, T
AU  - Mori T
FAU - Abe, K
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Drosophila Proteins)
RN  - 0 (Gfra1 protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor Receptors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Ret protein, Drosophila)
RN  - EC 2.7.10.1 (Ret protein, rat)
SB  - IM
MH  - Animals
MH  - Arterial Occlusive Diseases/*metabolism
MH  - Blotting, Western
MH  - *Cerebral Arteries
MH  - Cerebral Cortex/*metabolism
MH  - Corpus Striatum/*metabolism
MH  - *Drosophila Proteins
MH  - Glial Cell Line-Derived Neurotrophic Factor Receptors
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-ret
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
MH  - Staining and Labeling
MH  - Time Factors
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - S0006-8993(99)01563-2 [pii]
AID - 10.1016/s0006-8993(99)01563-2 [doi]
PST - ppublish
SO  - Brain Res. 1999 Jul 10;834(1-2):190-5. doi: 10.1016/s0006-8993(99)01563-2.