PMID- 10407028
OWN - NLM
STAT- MEDLINE
DCOM- 19990802
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 14
DP  - 1999 Jul 15
TI  - Disruption of a retinal guanylyl cyclase gene leads to cone-specific dystrophy
      and paradoxical rod behavior.
PG  - 5889-97
AB  - One of two orphan photoreceptor guanylyl cyclases that are highly conserved from 
      fish to mammals, GC-E (or retGC1) was eliminated by gene disruption. Expression
      of the second retinal cyclase (GC-F) as well as the numbers and morphology of
      rods remained unchanged in GC-E null mice. However, rods isolated from such mice,
      despite having a normal dark current, recovered from a light flash markedly
      faster. Unexpectedly, the a- and b-waves of electroretinograms (ERG) from
      dark-adapted null mice were suppressed markedly. Cones, initially present in
      normal numbers in the retina, disappeared by 5 weeks, based on ERG and histology.
      Thus, the GC-E-deficient mouse defines a model for cone dystrophy, but it also
      demonstrates that morphologically normal rods display paradoxical behavior in
      their responses to light.
FAU - Yang, R B
AU  - Yang RB
AD  - Department of Pharmacology, University of Texas Southwestern Medical Center,
      Dallas, Texas 75235-9050, USA.
FAU - Robinson, S W
AU  - Robinson SW
FAU - Xiong, W H
AU  - Xiong WH
FAU - Yau, K W
AU  - Yau KW
FAU - Birch, D G
AU  - Birch DG
FAU - Garbers, D L
AU  - Garbers DL
LA  - eng
GR  - EY05235/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Adaptation, Ocular
MH  - Animals
MH  - Darkness
MH  - Electroretinography
MH  - Exons
MH  - Guanylate Cyclase/deficiency/*genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Restriction Mapping
MH  - Retina/*enzymology
MH  - Retinal Cone Photoreceptor Cells/pathology/*physiology
MH  - Retinal Rod Photoreceptor Cells/pathology/*physiology
MH  - Retinitis Pigmentosa/*genetics/pathology/physiopathology
PMC - PMC6783089
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 Jul 15;19(14):5889-97.