PMID- 10406266
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20071115
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 94
IP  - 7
DP  - 1999 Jul
TI  - Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal 
      translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy 3.
PG  - 1951-4
AB  - A rare case of primary mucosa-associated lymphoid tissue lymphoma (MALT) of the
      rectum is reported. A 56-yr-old man was referred to our hospital for further
      examination and treatment of rectal neoplasm. A physical examination and
      laboratory data showed no special abnormalities. However, endoscopic colorectal
      observation revealed multiple red and slightly elevated nodular lesions with
      erosive changes of the rectum. The lesions were composed of diffuse, small
      atypical lymphoid cells (i.e., centrocyte-like cells) and were stained with L26
      and BCL-2 but not cyclin D1. Surface markers of cells obtained from biopsy
      specimens were CD5-, CD10-, CD19+, CD20+, kappa+, and lambda-. No BCL-2 gene
      rearrangement was observed. The clonal karyotype of t(11;18)(q21;q21) was
      observed in six of nine lymphoid cells. Trisomy was also identified two of 144
      cells by fluorescence in situ hybridization. We report a rare case of the rectal 
      MALT lymphoma bearing characteristic chromosomal aberrations; t(11;18)(q21;q21)
      and trisomy 3. We suggest that chromosomal analysis using biopsy specimens may be
      useful for the diagnosis of MALT lymphoma.
FAU - Hosaka, S
AU  - Hosaka S
AD  - The Second Department of Internal Medicine, Shinshu University School of
      Medicine, Matsumoto, Japan.
FAU - Akamatsu, T
AU  - Akamatsu T
FAU - Nakamura, S
AU  - Nakamura S
FAU - Kaneko, T
AU  - Kaneko T
FAU - Kitano, K
AU  - Kitano K
FAU - Kiyosawa, K
AU  - Kiyosawa K
FAU - Ota, H
AU  - Ota H
FAU - Hosaka, N
AU  - Hosaka N
FAU - Miyabayashi, H
AU  - Miyabayashi H
FAU - Katsuyama, T
AU  - Katsuyama T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 3
MH  - Humans
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Rectal Neoplasms/*genetics/pathology
MH  - *Translocation, Genetic
MH  - *Trisomy
EDAT- 1999/07/16 00:00
MHDA- 1999/07/16 00:01
CRDT- 1999/07/16 00:00
PHST- 1999/07/16 00:00 [pubmed]
PHST- 1999/07/16 00:01 [medline]
PHST- 1999/07/16 00:00 [entrez]
AID - S0002927099002932 [pii]
AID - 10.1111/j.1572-0241.1999.01237.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 1999 Jul;94(7):1951-4. doi: 10.1111/j.1572-0241.1999.01237.x.