PMID- 10405352 OWN - NLM STAT- MEDLINE DCOM- 19990824 LR - 20081121 IS - 0042-6822 (Print) IS - 0042-6822 (Linking) VI - 260 IP - 1 DP - 1999 Jul 20 TI - Complete circular DNA genome of a TT virus variant (isolate name SANBAN) and 44 partial ORF2 sequences implicating a great degree of diversity beyond genotypes. PG - 17-22 AB - Information on the entire genome of TT virus (TTV) has been scarce. The circular ssDNA genome of a variant (isolate name SANBAN) that we sequenced was only 56.7% homologous to the prototype isolate (TA278), with even lower homology at the amino acid level: 34.2% for ORF1 and 39.7% for ORF2. Regarding the ORF1, SANBAN was only very distantly related to the six major TTV genotypes reported to date. In partial ORF2 sequences determined on 44 isolates taken together, TTV has a broad range of genetic diversity and the SANBAN isolate may represent a new TTV-like viral species or genus and not merely a genotype of TTV. CI - Copyright 1999 Academic Press. FAU - Hijikata, M AU - Hijikata M AD - Department of Medical Sciences, Toshiba General Hospital, 6-3-22 Higashi Oh-i, Shinagawa-ku, Tokyo, 140-8522, Japan. FAU - Takahashi, K AU - Takahashi K FAU - Mishiro, S AU - Mishiro S LA - eng SI - GENBANK/AB024341 SI - GENBANK/AB024342 SI - GENBANK/AB024343 SI - GENBANK/AB024344 SI - GENBANK/AB024345 SI - GENBANK/AB024346 SI - GENBANK/AB024347 SI - GENBANK/AB024348 SI - GENBANK/AB024349 SI - GENBANK/AB024350 SI - GENBANK/AB024351 SI - GENBANK/AB024352 SI - GENBANK/AB024353 SI - GENBANK/AB024354 SI - GENBANK/AB024355 SI - GENBANK/AB024356 SI - GENBANK/AB024357 SI - GENBANK/AB024358 SI - GENBANK/AB024359 SI - GENBANK/AB024360 SI - GENBANK/AB024361 SI - GENBANK/AB024362 SI - GENBANK/AB024363 SI - GENBANK/AB024364 SI - GENBANK/AB024365 SI - GENBANK/AB024366 SI - GENBANK/AB024367 SI - GENBANK/AB024368 SI - GENBANK/AB024369 SI - GENBANK/AB024370 SI - etc. PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Virology JT - Virology JID - 0110674 RN - 0 (DNA, Circular) RN - 0 (DNA, Viral) RN - 0 (Viral Proteins) SB - IM MH - Amino Acid Sequence MH - Circoviridae/*genetics MH - DNA, Circular/*chemistry MH - DNA, Viral/*chemistry MH - *Genetic Variation MH - Genotype MH - Molecular Sequence Data MH - Nucleic Acid Conformation MH - *Open Reading Frames MH - Sequence Alignment MH - Viral Proteins/chemistry/genetics EDAT- 1999/07/16 00:00 MHDA- 1999/07/16 00:01 CRDT- 1999/07/16 00:00 PHST- 1999/07/16 00:00 [pubmed] PHST- 1999/07/16 00:01 [medline] PHST- 1999/07/16 00:00 [entrez] AID - 10.1006/viro.1999.9797 [doi] AID - S0042-6822(99)99797-0 [pii] PST - ppublish SO - Virology. 1999 Jul 20;260(1):17-22. doi: 10.1006/viro.1999.9797.