PMID- 10404311
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190921
IS  - 0919-8172 (Print)
IS  - 0919-8172 (Linking)
VI  - 6
IP  - 6
DP  - 1999 Jun
TI  - A case of complete testicular feminization: laparoscopic orchiectomy and analysis
      of androgen receptor gene mutation.
PG  - 327-30
AB  - BACKGROUND: Analysis of an androgen receptor gene mutation and a bilateral
      laparoscopic orchiectomy were performed on a 19-year-old patient diagnosed as a
      case of complete testicular feminization. METHODS: DNA sequencing of an androgen 
      receptor gene mutation and laparoscopic orchiectomy were performed. RESULTS: A
      novel point mutation substituting a proline residue (CCG) for a leucine residue
      (CTG) was observed in codon 892 of exon 8 in the hormone-binding domain of the
      androgen receptor gene. Bilateral intra-abdominal testes were resected
      uneventfully by means of laparoscopic orchiectomy. CONCLUSION: We conclude that
      genetic analysis of androgen receptor gene mutation is essential for diagnosis of
      teon and laparoscopic orchiectomy is a useful therapeutic alteration as a
      minimally invasive treatment.
FAU - Kanayama, H
AU  - Kanayama H
AD  - Department of Urology, School of Medicine, University of Tokushima, Japan.
      kanahiro@clin.med.tokushima-u.ac.jp
FAU - Naroda, T
AU  - Naroda T
FAU - Inoue, Y
AU  - Inoue Y
FAU - Kurokawa, Y
AU  - Kurokawa Y
FAU - Kagawa, S
AU  - Kagawa S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Int J Urol
JT  - International journal of urology : official journal of the Japanese Urological
      Association
JID - 9440237
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Androgen-Insensitivity Syndrome/*genetics/*surgery
MH  - DNA Mutational Analysis
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Laparoscopy
MH  - Male
MH  - *Orchiectomy
MH  - Point Mutation
MH  - Receptors, Androgen/*genetics
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1046/j.1442-2042.1999.00065.x [doi]
PST - ppublish
SO  - Int J Urol. 1999 Jun;6(6):327-30. doi: 10.1046/j.1442-2042.1999.00065.x.