PMID- 10404183
OWN - NLM
STAT- MEDLINE
DCOM- 19990802
LR  - 20071115
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 2
IP  - 7
DP  - 1999 Jul
TI  - Interactions between beta 2-syntrophin and a family of microtubule-associated
      serine/threonine kinases.
PG  - 611-7
AB  - A screen for proteins that interact with beta 2-syntrophin led to the isolation
      of MAST205 (microtubule-associated serine/threonine kinase-205 kD) and a newly
      identified homologue, SAST (syntrophin-associated serine/threonine kinase).
      Binding studies showed that beta 2-syntrophin and MAST205/SAST associated via a
      PDZ-PDZ domain interaction. MAST205 colocalized with beta 2-syntrophin and
      utrophin at neuromuscular junctions. SAST colocalized with syntrophin in cerebral
      vasculature, spermatic acrosomes and neuronal processes. SAST and syntrophin were
      highly associated with purified microtubules and microtubule-associated proteins,
      whereas utrophin and dystrophin were only partially associated with microtubules.
      Our data suggest that MAST205 and SAST link the dystrophin/utrophin network with 
      microtubule filaments via the syntrophins.
FAU - Lumeng, C
AU  - Lumeng C
AD  - Department of Human Genetics, University of Michigan Medical School, Ann Arbor
      48109-0618, USA.
FAU - Phelps, S
AU  - Phelps S
FAU - Crawford, G E
AU  - Crawford GE
FAU - Walden, P D
AU  - Walden PD
FAU - Barald, K
AU  - Barald K
FAU - Chamberlain, J S
AU  - Chamberlain JS
LA  - eng
SI  - GENBANK/AF077818
GR  - AR44533/AR/NIAMS NIH HHS/United States
GR  - P60AR20557/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Dystrophin-Associated Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Mtssk protein, mouse)
RN  - 0 (Recombinant Proteins)
RN  - 0 (syntrophin)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/enzymology
MH  - Cells, Cultured
MH  - Dystrophin-Associated Proteins
MH  - Hippocampus/enzymology
MH  - Male
MH  - Membrane Proteins/chemistry/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred mdx
MH  - Microtubule-Associated Proteins/chemistry/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/enzymology
MH  - Neurons/metabolism
MH  - Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism
MH  - Pyramidal Cells/enzymology
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Testis/enzymology
EDAT- 1999/07/15 10:00
MHDA- 2001/03/23 10:01
CRDT- 1999/07/15 10:00
PHST- 1999/07/15 10:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/07/15 10:00 [entrez]
AID - 10.1038/10165 [doi]
PST - ppublish
SO  - Nat Neurosci. 1999 Jul;2(7):611-7. doi: 10.1038/10165.