PMID- 10403791
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 260
IP  - 2
DP  - 1999 Jul 5
TI  - Genomic organization and chromosomal localization of the human CD163 (M130) gene:
      a member of the scavenger receptor cysteine-rich superfamily.
PG  - 466-74
AB  - The human protein CD163 (M130) is a member of the scavenger receptor
      cysteine-rich (SRCR) superfamily, which is exclusively expressed by monocytes and
      macrophages. Here, we investigated the genomic organization and the chromosomal
      localization of the human CD163 gene. The CD163 gene is composed of 17 exons and 
      16 introns and spans over 35 kb. Each of its nine SRCR domains is encoded by a
      separate exon, which is similar to other members of the group B SRCR subfamily.
      Two cytoplasmic variants of CD163 arise from alternative splicing of intron 15,
      while a truncated and an extracellular variant results from alternative splicing 
      of intron 5 or intron 7, respectively. Using fluorescence in situ hybridization
      we mapped this gene to the human chromosome 12p13. The transcription initiation
      sites of the CD163 gene were determined and the 5'-flanking region was sequenced.
      The nucleotide analysis revealed several putative binding sites for transcription
      factors, which have been shown to play an important role in myeloid specific gene
      expression. In addition, we identified a L1 element located 1.4 kb upstream of
      the major transcription initiation site.
CI  - Copyright 1999 Academic Press.
FAU - Ritter, M
AU  - Ritter M
AD  - Institute for Clinical Chemistry and Laboratory Medicine, University of
      Regensburg, Regensburg, D-93042, Germany.
FAU - Buechler, C
AU  - Buechler C
FAU - Langmann, T
AU  - Langmann T
FAU - Schmitz, G
AU  - Schmitz G
LA  - eng
SI  - GENBANK/AJ133107
SI  - GENBANK/AJ224687
SI  - GENBANK/Y18403
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scarb1 protein, mouse)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 9007-49-2 (DNA)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Alternative Splicing
MH  - *Antigens, CD
MH  - Antigens, Differentiation, Myelomonocytic/*genetics
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 12
MH  - Cysteine/*chemistry
MH  - DNA
MH  - Exons
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - *Membrane Proteins
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics
MH  - *Receptors, Cell Surface
MH  - Receptors, Immunologic/chemistry/*genetics
MH  - *Receptors, Lipoprotein
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B
MH  - Terminator Regions, Genetic
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1006/bbrc.1999.0866 [doi]
AID - S0006-291X(99)90866-5 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Jul 5;260(2):466-74. doi:
      10.1006/bbrc.1999.0866.