PMID- 10403781
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20161124
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 260
IP  - 2
DP  - 1999 Jul 5
TI  - APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine
      deaminase supergene family.
PG  - 398-404
AB  - APOBEC-1, which mediates the editing of apolipoprotein (apo) B mRNA, is the only 
      known member of the C (cytidine)-->U (uridine) editing enzyme subfamily of the
      cytidine deaminase supergene family. Here we report the cloning of APOBEC-2,
      another member of the subfamily. Human and mouse APOBEC-2 both contain 224 amino 
      acid residues, and their genes are mapped to syntenic regions of human chromosome
      6 (6p21) and mouse chromosome 17. By phylogenetic analysis, APOBEC-2 is shown to 
      be evolutionarily related to APOBEC-1, and analysis of substitution rates
      indicates that APOBEC-2 is a much better conserved gene than APOBEC-1. APOBEC-2
      mRNA and protein are expressed exclusively in heart and skeletal muscle. APOBEC-2
      does not display detectable apoB mRNA editing activity. Like other editing
      enzymes of the cytidine deaminase superfamily, APOBEC-2 has low, but definite,
      intrinsic cytidine deaminase activity. The identification of APOBEC-2 indicates
      that APOBEC-1 is not the only member of the C-->U editing enzyme subfamily,
      which, like the A (adenosine)-->I (inosine) subfamily of editing enzymes, must
      encompass at least two and possibly more different deaminase enzymes. It suggests
      that the C-->U editing affecting apoB mRNA and other RNAs is not an isolated
      event mediated by a single enzyme but involves multiple related proteins that
      have evolved from a primordial gene closely related to the housekeeping enzyme
      cytidine deaminase.
CI  - Copyright 1999 Academic Press.
FAU - Liao, W
AU  - Liao W
AD  - Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston,
      Texas, 77030-3498, USA.
FAU - Hong, S H
AU  - Hong SH
FAU - Chan, B H
AU  - Chan BH
FAU - Rudolph, F B
AU  - Rudolph FB
FAU - Clark, S C
AU  - Clark SC
FAU - Chan, L
AU  - Chan L
LA  - eng
SI  - GENBANK/AF161698
SI  - GENBANK/AF161699
GR  - HL-56668/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Muscle Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 3.5.4.5 (APOBEC Deaminases)
RN  - EC 3.5.4.5 (APOBEC2 protein, human)
RN  - EC 3.5.4.5 (Apobec2 protein, mouse)
RN  - EC 3.5.4.5 (Cytidine Deaminase)
SB  - IM
MH  - APOBEC Deaminases
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 6
MH  - Cytidine Deaminase/chemistry/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - *Muscle Proteins
MH  - Muscle, Skeletal/*enzymology
MH  - Myocardium/*enzymology
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - *RNA Editing
MH  - RNA, Messenger/genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1006/bbrc.1999.0925 [doi]
AID - S0006-291X(99)90925-7 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Jul 5;260(2):398-404. doi:
      10.1006/bbrc.1999.0925.