PMID- 10403649
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 6
DP  - 1999 Jun
TI  - The transcription factor c-Maf controls the production of interleukin-4 but not
      other Th2 cytokines.
PG  - 745-51
AB  - IL-4 promotes the differentiation of naive CD4+ T cells into IL-4-producing T
      helper 2 (Th2) cells. Previous work provided suggestive but not conclusive
      evidence that the transcription factor c-Maf directed the tissue-specific
      expression of IL-4. It was not known whether c-Maf controlled the transcription
      of other Th2 cytokine genes. To elucidate the role of c-Maf in vivo, we examined 
      cytokine production in mice lacking c-Maf (c-maf(-/-)). CD4+ T cells and NK T
      cells from c-maf(-/-) mice were markedly deficient in IL-4 production. However,
      the mice produced normal levels of IL-13 and IgE, and, when differentiated in the
      presence of exogenous IL-4, c-maf(-/-) T cells produced approximately normal
      levels of other Th2 cytokines. We conclude that c-Maf has a critical and
      selective function in IL-4 gene transcription in vivo.
FAU - Kim, J I
AU  - Kim JI
AD  - Department of Immunology and Infectious Diseases, Harvard School of Public
      Health, Boston, Massachusetts 02115-6017, USA.
FAU - Ho, I C
AU  - Ho IC
FAU - Grusby, M J
AU  - Grusby MJ
FAU - Glimcher, L H
AU  - Glimcher LH
LA  - eng
GR  - AI/AG 37833/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-5)
RN  - 0 (Maf protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-maf)
RN  - 0 (Transcription Factors)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
SB  - X
MH  - Animals
MH  - Cytokines/*physiology
MH  - DNA-Binding Proteins/metabolism/*physiology
MH  - Immunoglobulin E/metabolism
MH  - Interleukin-10/genetics/metabolism
MH  - Interleukin-13/metabolism
MH  - Interleukin-4/*biosynthesis/pharmacology
MH  - Interleukin-5/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Mutant Strains
MH  - Promoter Regions, Genetic/physiology
MH  - Proto-Oncogene Proteins/metabolism/*physiology
MH  - Proto-Oncogene Proteins c-maf
MH  - Spleen/cytology/drug effects
MH  - Th2 Cells/immunology/*metabolism
MH  - Transcription Factors/metabolism/*physiology
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - S1074-7613(00)80073-4 [pii]
AID - 10.1016/s1074-7613(00)80073-4 [doi]
PST - ppublish
SO  - Immunity. 1999 Jun;10(6):745-51. doi: 10.1016/s1074-7613(00)80073-4.