PMID- 10403644
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 6
DP  - 1999 Jun
TI  - The molecular characterization of the fetal stem cell marker AA4.
PG  - 691-700
AB  - We have identified and characterized the stem cell antigen AA4. This molecule is 
      a type I transmembrane protein whose overall structure suggests a role in cell
      adhesion. During fetal ontogeny (days 9-14 of development), AA4 is expressed in
      three major cell types: vascular endothelial cells, aorta-associated
      hematopoietic clusters, and primitive fetal liver hematopoietic progenitors. In
      the adult, AA4 is abundant in lung, heart, and whole bone marrow. In the adult
      hematopoietic compartment, aa4 transcripts are present in bone marrow CD34(-/lo) 
      Lin- Sca-1+ c-Kit+ and CD34hi Lin- Sca-1+ c-Kit+ stem and progenitor cell
      subsets. Our observations suggest that AA4 plays a role in cell-cell interactions
      during hematopoietic and vascular development.
FAU - Petrenko, O
AU  - Petrenko O
AD  - Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
FAU - Beavis, A
AU  - Beavis A
FAU - Klaine, M
AU  - Klaine M
FAU - Kittappa, R
AU  - Kittappa R
FAU - Godin, I
AU  - Godin I
FAU - Lemischka, I R
AU  - Lemischka IR
LA  - eng
SI  - GENBANK/AF081789
GR  - R01 CA 45339/CA/NCI NIH HHS/United States
GR  - R01 DK 42989/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, Surface)
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, Surface/biosynthesis/*chemistry
MH  - Base Sequence
MH  - Biomarkers/chemistry
MH  - Cloning, Molecular
MH  - Fetus/*immunology
MH  - Hematopoietic Stem Cells/chemistry/*immunology/metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - RNA, Messenger/analysis
MH  - Recombinant Proteins/biosynthesis
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - S1074-7613(00)80068-0 [pii]
AID - 10.1016/s1074-7613(00)80068-0 [doi]
PST - ppublish
SO  - Immunity. 1999 Jun;10(6):691-700. doi: 10.1016/s1074-7613(00)80068-0.