PMID- 10403390
OWN - NLM
STAT- MEDLINE
DCOM- 19990802
LR  - 20211203
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 453
IP  - 1-2
DP  - 1999 Jun 18
TI  - Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt
      diet-treated rat adrenal.
PG  - 135-9
AB  - PCR-coupled cDNA subtraction hybridization was adapted to identify the genes
      expressed in the adrenocortical tissues from high salt diet-treated rat. A novel 
      cDNA clone, termed salt-inducible kinase (SIK), encoding a polypeptide (776 amino
      acids) with significant similarity to protein serine/ threonine kinases in the
      SNF1/AMPK family was isolated. An in vitro kinase assay demonstrated that SIK
      protein had autophosphorylation activity. Northern blot revealed that SIK mRNA
      levels were markedly augmented by ACTH treatment both in rat adrenal glands and
      in Y1 cells. SIK may play an important role in the regulation of adrenocortical
      functions in response to high plasma salt and ACTH stimulation.
FAU - Wang, Z
AU  - Wang Z
AD  - Department of Molecular Physiological Chemistry, Osaka University Medical School,
      Suita, Japan.
FAU - Takemori, H
AU  - Takemori H
FAU - Halder, S K
AU  - Halder SK
FAU - Nonaka, Y
AU  - Nonaka Y
FAU - Okamoto, M
AU  - Okamoto M
LA  - eng
SI  - GENBANK/AB020480
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Potassium, Dietary)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (SNF1-related protein kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Sik1 protein, rat)
RN  - EC 2.7.11.3 (AMP-Activated Protein Kinase Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinase Kinases
MH  - Adrenal Cortex/cytology/drug effects
MH  - Adrenal Cortex Neoplasms
MH  - Adrenal Glands/*enzymology
MH  - Adrenocorticotropic Hormone/pharmacology
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Gene Expression/drug effects
MH  - Molecular Sequence Data
MH  - Potassium, Dietary/*pharmacology
MH  - Protein Kinases/genetics
MH  - Protein Serine-Threonine Kinases/chemistry/*genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Sodium Chloride, Dietary/*pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - S0014579399007085 [pii]
AID - 10.1016/s0014-5793(99)00708-5 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jun 18;453(1-2):135-9. doi: 10.1016/s0014-5793(99)00708-5.