PMID- 10403125
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20190915
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 22
IP  - 3
DP  - 1999 Jun
TI  - Developmental patterns of GalBeta1,3(4)GlcNAc alpha2,3-sialyltransferase (ST3Gal 
      III) expression in the mouse: in situ hybridization using DIG-labeled RNA probes.
PG  - 243-8
AB  - Sialic acids are key determinants for biological processes, such as cell-cell
      interaction and differentiation. Sialyltransferases contribute to the diversity
      in carbohydrate structure through their attachment of sialic acid in various
      terminal positions on glycolipid and glycoprotein (N-linked and O-linked)
      carbohydrate groups. Galbeta 1,3(4)GlcNAc alpha2,3-sialyltransferase (ST3Gal III)
      is involved in the biosynthesis of sLe(x)and sLe(a) known as selectin ligands and
      tumor-associated carbohydrate structures. The appearance and differential
      distribution of ST3Gal III mRNA during mice embryogenesis [embryonic (E) days;
      E9, E11, E13, E15] were investigated by in situ hybridization with
      digoxigenin-labeled RNA probes coupled with alkaline phosphatase detection. On
      E9, all tissues were positive for ST3Gal III mRNA expression, whereas ST3Gal III 
      mRNA on E11 was not detected throughout all tissues. On E13, ST3Gal III mRNA was 
      expressed in different manner in various tissues. In this stage, ST3Gal III mRNA 
      was positive only in the liver, pancreas and bladder. On E15, specific signal for
      ST3Gal III was detected in the liver, lung and forebrain. These results indicate 
      that ST3GAI III is differently expressed at developmental stages of mice embryo, 
      and this may be importantly related with regulation of organogenesis in mice.
FAU - Ji, M Y
AU  - Ji MY
AD  - Division of Biological Science, College of Natural Sciences, Wonkwang University,
      Iksan, Korea.
FAU - Lee, Y C
AU  - Lee YC
FAU - Kim, K S
AU  - Kim KS
FAU - Cho, J W
AU  - Cho JW
FAU - Jung, K Y
AU  - Jung KY
FAU - Kim, C H
AU  - Kim CH
FAU - Choo, Y K
AU  - Choo YK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (RNA Probes)
RN  - 0 (RNA, Messenger)
RN  - EC 2.4.99.- (Sialyltransferases)
RN  - EC 2.4.99.4 (beta-galactoside alpha-2,3-sialyltransferase)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - NQ1SX9LNAU (Digoxigenin)
SB  - IM
MH  - Alkaline Phosphatase/*analysis
MH  - Animals
MH  - Digoxigenin/chemistry
MH  - Embryo, Mammalian/*enzymology
MH  - Embryonic and Fetal Development
MH  - Female
MH  - In Situ Hybridization/*methods
MH  - Mice
MH  - Pregnancy
MH  - RNA Probes/*genetics
MH  - RNA, Messenger/*genetics
MH  - Sialyltransferases/*genetics
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - 10.1007/bf02976357 [doi]
PST - ppublish
SO  - Arch Pharm Res. 1999 Jun;22(3):243-8. doi: 10.1007/bf02976357.