PMID- 10402669
OWN - NLM
STAT- MEDLINE
DCOM- 19990812
LR  - 20061115
IS  - 0192-253X (Print)
IS  - 0192-253X (Linking)
VI  - 25
IP  - 1
DP  - 1999
TI  - Trophoblast giant cells express NF-kappa B2 during early mouse development.
PG  - 23-30
AB  - To investigate whether transcription factors of the NF-kappa B family could play 
      a role in early mammalian development, we have analyzed the expression of nfkb1, 
      nfkb2, c-Rel, RelA, RelB, and bcl-3 from 6.5- to 10.5-day mouse embryo
      implantation sites. Our study shows that nfkb2 mRNA and protein are specifically 
      localized in trophoblast giant cells throughout the stages analyzed. Trophoblast 
      giant cells obtained upon in vitro cultures of 7.5-day ectoplacental cones
      display NF-kappa B DNA-binding activity that is supershifted by the anti-NF-kappa
      B2 antibody. Trophoblast giant cells are embryo-derived cells that form an
      interface between embryonic and maternal tissues during early mouse development; 
      they are involved in decidual remodeling and expansion of the embryonic cavity,
      placenta formation, and possibly avoidance of maternal immune response to the
      embryo. Our study suggests that NF-kappa B2 could play a role in the modulation
      of genes expressed in trophoblast giant cells during the course of early
      embryogenesis, and therefore be relevant for tissue remodeling and morphogenesis 
      of placenta.
FAU - Muggia, A
AU  - Muggia A
AD  - Dipartimento di Genetica e Biologia dei Microrganismi dell'Universita di Milano, 
      Italy.
FAU - Teesalu, T
AU  - Teesalu T
FAU - Neri, A
AU  - Neri A
FAU - Blasi, F
AU  - Blasi F
FAU - Talarico, D
AU  - Talarico D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Genet
JT  - Developmental genetics
JID - 7909963
RN  - 0 (DNA Primers)
RN  - 0 (NF-kappa B)
RN  - 0 (NF-kappa B p52 Subunit)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cells, Cultured
MH  - DNA Primers
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Giant Cells/*metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice
MH  - NF-kappa B/*genetics
MH  - NF-kappa B p52 Subunit
MH  - RNA, Messenger/genetics
MH  - Trophoblasts/*metabolism
EDAT- 1999/07/14 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/07/14 10:00
PHST- 1999/07/14 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/07/14 10:00 [entrez]
AID - 10.1002/(SICI)1520-6408(1999)25:1<23::AID-DVG3>3.0.CO;2-K [pii]
AID - 10.1002/(SICI)1520-6408(1999)25:1<23::AID-DVG3>3.0.CO;2-K [doi]
PST - ppublish
SO  - Dev Genet. 1999;25(1):23-30. doi:
      10.1002/(SICI)1520-6408(1999)25:1<23::AID-DVG3>3.0.CO;2-K.