PMID- 10402196
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 1
DP  - 1999 May
TI  - Role of alpha9 nicotinic ACh receptor subunits in the development and function of
      cochlear efferent innervation.
PG  - 93-103
AB  - Cochlear outer hair cells (OHCs) express alpha9 nACh receptors and are contacted 
      by descending, predominately cholinergic, efferent fibers originating in the CNS.
      Mice carrying a null mutation for the nACh alpha9 gene were produced to
      investigate its role(s) in auditory processing and development of hair cell
      innervation. In alpha9 knockout mice, most OHCs were innervated by one large
      terminal instead of multiple smaller terminals as in wild types, suggesting a
      role for the nACh alpha9 subunit in development of mature synaptic connections.
      Alpha9 knockout mice also failed to show suppression of cochlear responses
      (compound action potentials, distortion product otoacoustic emissions) during
      efferent fiber activation, demonstrating the key role alpha9 receptors play in
      mediating the only known effects of the olivocochlear system.
FAU - Vetter, D E
AU  - Vetter DE
AD  - The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
      vetter@salk.edu
FAU - Liberman, M C
AU  - Liberman MC
FAU - Mann, J
AU  - Mann J
FAU - Barhanin, J
AU  - Barhanin J
FAU - Boulter, J
AU  - Boulter J
FAU - Brown, M C
AU  - Brown MC
FAU - Saffiote-Kolman, J
AU  - Saffiote-Kolman J
FAU - Heinemann, S F
AU  - Heinemann SF
FAU - Elgoyhen, A B
AU  - Elgoyhen AB
LA  - eng
GR  - P50 DA005010/DA/NIDA NIH HHS/United States
GR  - DC00188/DC/NIDCD NIH HHS/United States
GR  - DC02871/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Receptors, Nicotinic)
SB  - IM
MH  - Animals
MH  - Cochlea/cytology/*innervation/physiology
MH  - Efferent Pathways/growth & development/physiology
MH  - Hair Cells, Auditory, Outer/physiology
MH  - Mice
MH  - Mice, Knockout/genetics
MH  - Olivary Nucleus/physiology
MH  - Receptors, Nicotinic/genetics/*physiology
EDAT- 1999/07/13 00:00
MHDA- 1999/07/13 00:01
CRDT- 1999/07/13 00:00
PHST- 1999/07/13 00:00 [pubmed]
PHST- 1999/07/13 00:01 [medline]
PHST- 1999/07/13 00:00 [entrez]
AID - S0896-6273(00)80756-4 [pii]
AID - 10.1016/s0896-6273(00)80756-4 [doi]
PST - ppublish
SO  - Neuron. 1999 May;23(1):93-103. doi: 10.1016/s0896-6273(00)80756-4.