PMID- 10402192
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20190606
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 1
DP  - 1999 May
TI  - latheo encodes a subunit of the origin recognition complex and disrupts neuronal 
      proliferation and adult olfactory memory when mutant.
PG  - 45-54
AB  - The Drosophila latheo (lat) gene was identified in a behavioral screen for
      olfactory memory mutants. The original hypomorphic latP1 mutant (Boynton and
      Tully, 1992) shows a structural defect in adult brain. Homozygous lethal lat
      mutants lack imaginal discs, show little cell proliferation in the CNS of third
      instar larvae, and die as early pupae. latP1 was cloned, and all of the above
      mentioned defects of hypomorphic or homozygous lethal lat mutants were rescued
      with a lat+ transgene. lat encodes a novel protein with homology to a subunit of 
      the origin recognition complex (ORC). Human and Drosophila LAT both associate
      with ORC2 and are related to yeast ORC3, suggesting that LAT functions in DNA
      replication during cell proliferation.
FAU - Pinto, S
AU  - Pinto S
AD  - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
FAU - Quintana, D G
AU  - Quintana DG
FAU - Smith, P
AU  - Smith P
FAU - Mihalek, R M
AU  - Mihalek RM
FAU - Hou, Z H
AU  - Hou ZH
FAU - Boynton, S
AU  - Boynton S
FAU - Jones, C J
AU  - Jones CJ
FAU - Hendricks, M
AU  - Hendricks M
FAU - Velinzon, K
AU  - Velinzon K
FAU - Wohlschlegel, J A
AU  - Wohlschlegel JA
FAU - Austin, R J
AU  - Austin RJ
FAU - Lane, W S
AU  - Lane WS
FAU - Tully, T
AU  - Tully T
FAU - Dutta, A
AU  - Dutta A
LA  - eng
SI  - GENBANK/AF093535
SI  - GENBANK/AF152093
SI  - GENBANK/AF153209
GR  - GM18170/GM/NIGMS NIH HHS/United States
GR  - R01 CA060499/CA/NCI NIH HHS/United States
GR  - R01 CA060499-06/CA/NCI NIH HHS/United States
GR  - NS32480/NS/NINDS NIH HHS/United States
GR  - CA60499/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Orc2 protein, Drosophila)
RN  - 0 (Orc3 protein, Drosophila)
RN  - 0 (Origin Recognition Complex)
SB  - IM
CIN - Neuron. 1999 May;23(1):1-2. PMID: 10402184
MH  - Amino Acid Sequence/genetics
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Brain/abnormalities/pathology/physiopathology
MH  - Cell Division/physiology
MH  - Central Nervous System/pathology
MH  - Congenital Abnormalities/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila/*genetics/growth & development
MH  - *Drosophila Proteins
MH  - Memory/*physiology
MH  - Memory Disorders/genetics
MH  - Molecular Sequence Data
MH  - Mutation/*genetics/physiology
MH  - Neurons/*pathology
MH  - Olfactory Pathways/*physiopathology
MH  - Origin Recognition Complex
MH  - Pupa/physiology
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic/genetics
MH  - Transgenes/physiology
EDAT- 1999/07/13 00:00
MHDA- 1999/07/13 00:01
CRDT- 1999/07/13 00:00
PHST- 1999/07/13 00:00 [pubmed]
PHST- 1999/07/13 00:01 [medline]
PHST- 1999/07/13 00:00 [entrez]
AID - S0896-6273(00)80752-7 [pii]
PST - ppublish
SO  - Neuron. 1999 May;23(1):45-54.