PMID- 10399917
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 7
DP  - 1999 Jun 25
TI  - RAGE mediates a novel proinflammatory axis: a central cell surface receptor for
      S100/calgranulin polypeptides.
PG  - 889-901
AB  - S100/calgranulin polypeptides are present at sites of inflammation, likely
      released by inflammatory cells targeted to such loci by a range of environmental 
      cues. We report here that receptor for AGE (RAGE) is a central cell surface
      receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and
      related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with
      cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers
      cellular activation, with generation of key proinflammatory mediators. Blockade
      of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis
      in murine models by arresting activation of central signaling pathways and
      expression of inflammatory gene mediators. These data highlight a novel paradigm 
      in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular
      activation and tissue injury.
FAU - Hofmann, M A
AU  - Hofmann MA
AD  - College of Physicians and Surgeons, Columbia University, New York, New York
      10032, USA.
FAU - Drury, S
AU  - Drury S
FAU - Fu, C
AU  - Fu C
FAU - Qu, W
AU  - Qu W
FAU - Taguchi, A
AU  - Taguchi A
FAU - Lu, Y
AU  - Lu Y
FAU - Avila, C
AU  - Avila C
FAU - Kambham, N
AU  - Kambham N
FAU - Bierhaus, A
AU  - Bierhaus A
FAU - Nawroth, P
AU  - Nawroth P
FAU - Neurath, M F
AU  - Neurath MF
FAU - Slattery, T
AU  - Slattery T
FAU - Beach, D
AU  - Beach D
FAU - McClary, J
AU  - McClary J
FAU - Nagashima, M
AU  - Nagashima M
FAU - Morser, J
AU  - Morser J
FAU - Stern, D
AU  - Stern D
FAU - Schmidt, A M
AU  - Schmidt AM
LA  - eng
SI  - GENBANK/AF011757
GR  - DK52495/DK/NIDDK NIH HHS/United States
GR  - HL56881/HL/NHLBI NIH HHS/United States
GR  - HL60901/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Peptides)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (S100 Proteins)
RN  - 0 (S100A12 Protein)
RN  - 0 (S100A12 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cattle
MH  - Colitis/immunology
MH  - DNA, Complementary
MH  - Endothelium, Vascular/cytology
MH  - Female
MH  - Humans
MH  - Jurkat Cells
MH  - Leukocytes, Mononuclear/cytology/immunology
MH  - Membrane Proteins/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Peptides/genetics/*immunology
MH  - Phagocytes/cytology/immunology
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*immunology
MH  - S100 Proteins/genetics/*immunology
MH  - S100A12 Protein
EDAT- 1999/07/10 00:00
MHDA- 1999/07/10 00:01
CRDT- 1999/07/10 00:00
PHST- 1999/07/10 00:00 [pubmed]
PHST- 1999/07/10 00:01 [medline]
PHST- 1999/07/10 00:00 [entrez]
AID - S0092-8674(00)80801-6 [pii]
AID - 10.1016/s0092-8674(00)80801-6 [doi]
PST - ppublish
SO  - Cell. 1999 Jun 25;97(7):889-901. doi: 10.1016/s0092-8674(00)80801-6.