PMID- 10398684
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 13
DP  - 1999 Jul 1
TI  - Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in
      developing dorsal root ganglia.
PG  - 1717-28
AB  - Different classes of sensory neurons in dorsal root ganglia (DRG) are generated
      in two waves: large-diameter trkC+ and trkB+ neurons are born first, followed by 
      small-diameter trkA+ neurons. All such neurons require either neurogenin (ngn) 1 
      or 2, two neuronal determination genes encoding basic helix-loop-helix (bHLH)
      transcription factors. ngn2 is required primarily if not exclusively for the
      generation of trkC+ and trkB+ neurons, whereas the generation of most or all
      trkA+ neurons requires ngn1. Comparison with previous lineage tracing data in the
      chick suggests that this dichotomy reflects a requirement for the two ngns in
      distinct sensory precursor populations. The neurogenesis defect in ngn2(-/-)
      embryos is transient and later compensated by ngn1-dependent precursors,
      suggesting that feedback or competitive interactions between these precursors may
      control the proportion of different neuronal subtypes they normally produce.
      These data reveal remarkable parallels in the roles of bHLH factors during
      neurogenesis in the DRG, and myogenesis in the neighboring myotome.
FAU - Ma, Q
AU  - Ma Q
AD  - Howard Hughes Medical Institute, Division of Biology, California Institute of
      Technology, Pasadena, California 91125, USA.
FAU - Fode, C
AU  - Fode C
FAU - Guillemot, F
AU  - Guillemot F
FAU - Anderson, D J
AU  - Anderson DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (NEUROG2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurog2 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 0 (neurogenin, Xenopus)
RN  - 182238-50-2 (Neurog1 protein, mouse)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Embryonic and Fetal Development/genetics
MH  - Ganglia, Spinal/*embryology
MH  - Genes, Overlapping
MH  - Genotype
MH  - Gestational Age
MH  - In Situ Hybridization
MH  - In Situ Nick-End Labeling
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Neurologic Mutants
MH  - Morphogenesis/genetics
MH  - Nerve Tissue Proteins/genetics/*physiology
MH  - Neurons, Afferent/*cytology
MH  - Proto-Oncogene Proteins/*biosynthesis/genetics
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis/genetics
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkA
MH  - Receptors, Nerve Growth Factor/*biosynthesis/genetics
MH  - *Transcription Factors
MH  - *Xenopus Proteins
PMC - PMC316844
EDAT- 1999/07/10 00:00
MHDA- 1999/07/10 00:01
CRDT- 1999/07/10 00:00
PHST- 1999/07/10 00:00 [pubmed]
PHST- 1999/07/10 00:01 [medline]
PHST- 1999/07/10 00:00 [entrez]
AID - 10.1101/gad.13.13.1717 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Jul 1;13(13):1717-28. doi: 10.1101/gad.13.13.1717.