PMID- 10398678
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 13
DP  - 1999 Jul 1
TI  - NeuroD is required for differentiation of the granule cells in the cerebellum and
      hippocampus.
PG  - 1647-52
AB  - NeuroD, a bHLH transcription factor, is implicated in differentiation of neurons 
      and pancreatic beta cells. NeuroD-null mice die shortly after birth due to severe
      neonatal diabetes. To examine if there is postnatal neuronal phenotype in these
      mice, we rescued them from neonatal lethality by introducing a transgene encoding
      the mouse neuroD gene under the insulin promoter. These mice survive to adulthood
      but display severe neurological phenotype due to neuronal deficit in the granule 
      layers of the cerebellum and hippocampus. We show here that NeuroD is required
      for these postnatally generated microneurons to undergo proper differentiation,
      the absence of which results in cell death.
FAU - Miyata, T
AU  - Miyata T
AD  - Department of Molecular, Cellular, and Developmental Biology, University of
      Colorado at Boulder, Boulder, Colorado 80309-0347, USA.
FAU - Maeda, T
AU  - Maeda T
FAU - Lee, J E
AU  - Lee JE
LA  - eng
GR  - R01NS35118/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Insulin)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 169238-82-8 (NeuroD protein)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cell Count
MH  - Cell Differentiation
MH  - Cerebellum/*cytology/growth & development/pathology
MH  - Genetic Therapy
MH  - Hippocampus/*cytology/growth & development/pathology
MH  - In Situ Nick-End Labeling
MH  - Insulin/genetics
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Neurologic Mutants
MH  - Mice, Transgenic
MH  - Nerve Tissue Proteins/deficiency/genetics/*physiology
MH  - Neurons/*cytology
MH  - Phenotype
MH  - Promoter Regions, Genetic
MH  - Recombinant Fusion Proteins/physiology
MH  - Transgenes
PMC - PMC316850
EDAT- 1999/07/10 00:00
MHDA- 1999/07/10 00:01
CRDT- 1999/07/10 00:00
PHST- 1999/07/10 00:00 [pubmed]
PHST- 1999/07/10 00:01 [medline]
PHST- 1999/07/10 00:00 [entrez]
AID - 10.1101/gad.13.13.1647 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Jul 1;13(13):1647-52. doi: 10.1101/gad.13.13.1647.