PMID- 10398604
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5425
DP  - 1999 Jul 9
TI  - BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
PG  - 260-3
AB  - The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble
      and membrane-bound proteins that regulate immune responses. A member of the human
      TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell
      proliferation and immunoglobulin secretion. BLyS expression on human monocytes
      could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B 
      cell growth factor in costimulation assays. Administration of soluble recombinant
      BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum 
      immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its 
      receptor expression on B-lineage cells. The biological profile of BLyS suggests
      it is involved in monocyte-driven B cell activation.
FAU - Moore, P A
AU  - Moore PA
AD  - Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
FAU - Belvedere, O
AU  - Belvedere O
FAU - Orr, A
AU  - Orr A
FAU - Pieri, K
AU  - Pieri K
FAU - LaFleur, D W
AU  - LaFleur DW
FAU - Feng, P
AU  - Feng P
FAU - Soppet, D
AU  - Soppet D
FAU - Charters, M
AU  - Charters M
FAU - Gentz, R
AU  - Gentz R
FAU - Parmelee, D
AU  - Parmelee D
FAU - Li, Y
AU  - Li Y
FAU - Galperina, O
AU  - Galperina O
FAU - Giri, J
AU  - Giri J
FAU - Roschke, V
AU  - Roschke V
FAU - Nardelli, B
AU  - Nardelli B
FAU - Carrell, J
AU  - Carrell J
FAU - Sosnovtseva, S
AU  - Sosnovtseva S
FAU - Greenfield, W
AU  - Greenfield W
FAU - Ruben, S M
AU  - Ruben SM
FAU - Olsen, H S
AU  - Olsen HS
FAU - Fikes, J
AU  - Fikes J
FAU - Hilbert, D M
AU  - Hilbert DM
LA  - eng
SI  - GENBANK/AF132600
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (B-Cell Activation Factor Receptor)
RN  - 0 (BLyS receptor)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNFRSF13C protein, human)
RN  - 0 (TNFSF13B protein, human)
RN  - 0 (Tnfrsf13c protein, mouse)
RN  - 0 (Tnfsf13b protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - B-Cell Activating Factor
MH  - B-Cell Activation Factor Receptor
MH  - B-Lymphocyte Subsets/immunology
MH  - B-Lymphocytes/*immunology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Humans
MH  - Immunoglobulins/blood
MH  - Interferon-gamma/pharmacology
MH  - *Lymphocyte Activation
MH  - Membrane Proteins/chemistry/genetics/pharmacology/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Monocytes/*immunology
MH  - Receptors, Cytokine/metabolism
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Recombinant Proteins/pharmacology
MH  - Sequence Alignment
MH  - Species Specificity
MH  - Tumor Necrosis Factor-alpha/chemistry/genetics/pharmacology/*physiology
MH  - Up-Regulation
EDAT- 1999/07/10 00:00
MHDA- 1999/07/10 00:01
CRDT- 1999/07/10 00:00
PHST- 1999/07/10 00:00 [pubmed]
PHST- 1999/07/10 00:01 [medline]
PHST- 1999/07/10 00:00 [entrez]
AID - 7659 [pii]
AID - 10.1126/science.285.5425.260 [doi]
PST - ppublish
SO  - Science. 1999 Jul 9;285(5425):260-3. doi: 10.1126/science.285.5425.260.