PMID- 10397750
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 94
IP  - 2
DP  - 1999 Jul 15
TI  - Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis.
PG  - 818-24
AB  - About 80% of all cases of Fanconi anemia (FA) can be accounted for by
      complementation groups A and C. To understand the relationship between these
      groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca)
      during embryogenesis and compared it with the known pattern of the group-C gene
      (Fancc). Northern analysis of RNA from mouse embryos at embryonic days 7, 11, 15,
      and 17 showed a predominant 4.5 kb band in all stages. By in situ hybridization, 
      Fanca transcripts were found in the whisker follicles, teeth, brain, retina,
      kidney, liver, and limbs. There was also stage-specific variation in Fanca
      expression, particularly within the developing whiskers and the brain. Some
      tissues known to express Fancc (eg, gut) failed to show Fanca expression. These
      observations show that (1) Fanca is under both tissue- and stage-specific
      regulation in several tissues; (2) the expression pattern of Fanca is consistent 
      with the phenotype of the human disease; and (3) Fanca expression is not
      necessarily coupled to that of Fancc. The presence of distinct tissue targets for
      FA genes suggests that some of the variability in the clinical phenotype can be
      attributed to the complementation group assignment.
FAU - Abu-Issa, R
AU  - Abu-Issa R
AD  - Departments of Molecular and Human Genetics, Biochemistry, and Medicine, The
      Developmental Biology Program, Baylor College of Medicine, Houston, TX, USA.
FAU - Eichele, G
AU  - Eichele G
FAU - Youssoufian, H
AU  - Youssoufian H
LA  - eng
GR  - HL52138/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (FANCA protein, human)
RN  - 0 (Fanca protein, mouse)
RN  - 0 (Fanconi Anemia Complementation Group A Protein)
RN  - 0 (Fetal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proteins)
SB  - IM
MH  - Ameloblasts/metabolism
MH  - Animals
MH  - Brain/embryology/metabolism
MH  - DNA, Complementary/genetics
MH  - *DNA-Binding Proteins
MH  - Embryonic and Fetal Development/*genetics
MH  - Epithelium/metabolism
MH  - Extremities/embryology
MH  - Eye Proteins/biosynthesis/genetics
MH  - Fanconi Anemia/*genetics/pathology
MH  - Fanconi Anemia Complementation Group A Protein
MH  - Fetal Proteins/*biosynthesis/genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - In Situ Hybridization
MH  - Kidney/embryology/metabolism
MH  - Liver/embryology/metabolism
MH  - Mesoderm/metabolism
MH  - Mice
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - Odontoblasts/metabolism
MH  - Organ Specificity
MH  - Phenotype
MH  - *Protein Biosynthesis
MH  - Proteins/genetics
MH  - Vibrissae/embryology/metabolism
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - S0006-4971(20)67472-9 [pii]
PST - ppublish
SO  - Blood. 1999 Jul 15;94(2):818-24.