PMID- 10397741
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20071115
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 94
IP  - 2
DP  - 1999 Jul 15
TI  - NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with
      chromosome translocation t(1;11)(q23;p15).
PG  - 741-7
AB  - The nucleoporin gene NUP98 was found fused to the HOXA9, HOXD13, or DDX10 genes
      in human acute myelogenous leukemia (AML) with chromosome translocations
      t(7;11)(p15;p15), t(2;11)(q35;p15), or inv(11)(p15;q22), respectively. We report 
      here the fusion between the NUP98 gene and another homeobox gene PMX1 in a case
      of human AML with a t(1;11)(q23;p15) translocation. The chimeric NUP98-PMX1
      transcript was detected; however, there was no reciprocal PMX1-NUP98 fusion
      transcript. Like the NUP98-HOXA9 fusion, NUP98 and PMX1 were fused in frame and
      the N-terminal GLFG-rich docking region of the NUP98 and the PMX1 homeodomain
      were conserved in the NUP98-PMX1 fusion, suggesting that PMX1 homeodomain
      expression is upregulated and that the fusion protein may act as an oncogenic
      transcription factor. The fusion to NUP98 results in the addition of the strong
      transcriptional activation domain located in the N-terminal region of NUP98 to
      PMX1. These findings suggest that constitutive expression and alteration of the
      transcriptional activity of the PMX1 homeodomain protein may be critical for
      myeloid leukemogenesis.
FAU - Nakamura, T
AU  - Nakamura T
AD  - PRESTO, Japan Science and Technology Corp, Tokyo, Japan; The Cancer Institute,
      Japanese Foundation for Cancer Research, Tokyo, Japan.
      takuro-ind@unin.u-tokyo.ac.jp
FAU - Yamazaki, Y
AU  - Yamazaki Y
FAU - Hatano, Y
AU  - Hatano Y
FAU - Miura, I
AU  - Miura I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (NUP98-PMX1 fusion protein, human)
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - AIM
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - Chromosomes, Human, Pair 1/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 11/*genetics/ultrastructure
MH  - Female
MH  - Gene Expression Regulation, Leukemic
MH  - *Genes, Homeobox
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - *Nuclear Pore Complex Proteins
MH  - Oncogene Proteins, Fusion/chemistry/*genetics
MH  - Protein Conformation
MH  - Transcription, Genetic
MH  - *Translocation, Genetic
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
PST - ppublish
SO  - Blood. 1999 Jul 15;94(2):741-7.