PMID- 10397631
OWN - NLM
STAT- MEDLINE
DCOM- 19990804
LR  - 20071114
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 57
IP  - 1
DP  - 1999 Jul 1
TI  - Conserved and divergent expression patterns of the proteolipid protein gene
      family in the amphibian central nervous system.
PG  - 13-22
AB  - The recent discovery of a proteolipid protein gene family has revealed that its
      members are in fact widely distributed and are not exclusively associated with
      myelination. To date, three different gene products, DMalpha/DM-20/PLP,
      DMbeta/M6a, and DMgamma/M6b, have been isolated from certain primitive fish
      species, mouse, and human central nervous system (CNS). We cloned Xenopus laevis 
      orthologues of DMbeta/M6a and DMgamma/M6b and investigated the expression
      patterns of these gene transcripts as well as that of PLP in developing Xenopus
      CNS. As is the case in shark and mouse, the mRNA encoding the major myelin
      integral protein, PLP, is first detected at stage 42/43 in tadpoles and is
      exclusively found in morphologically recognizable oligodendrocytes throughout the
      brain, while DMbeta mRNA is solely expressed in young presumptive neurons in the 
      gray matter. There exist two distinct DMgamma mRNAs and, in contrast to these
      evolutionarily conserved expression patterns, DMgamma mRNAs distribute uniquely
      within the ventricular zone in young tadpoles (stage 25) through maturity.
      Furthermore, both DMbeta and DMgamma are expressed in the developing retina, and 
      their distributions are different from one other. In Xenopus CNS, therefore, the 
      expression patterns of three proteolipid proteins, PLP, DMbeta, and DMgamma, are 
      distinct from each other, implying very different roles for their protein
      products within the cell populations in which they are expressed.
FAU - Yoshida, M
AU  - Yoshida M
AD  - The Brookdale Center for Biochemistry and Molecular Biology, Mount Sinai School
      of Medicine, New York, New York 10029, USA. yoshida@msvax.mssm.edu
FAU - Shan, W S
AU  - Shan WS
FAU - Colman, D R
AU  - Colman DR
LA  - eng
GR  - NS20147/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Proteolipids)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Central Nervous System/anatomy & histology/embryology/*metabolism
MH  - Conserved Sequence
MH  - Embryo, Nonmammalian
MH  - Eye/embryology/metabolism
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Proteolipids/*biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Sharks
MH  - Xenopus laevis
EDAT- 1999/07/09 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/07/09 10:00
PHST- 1999/07/09 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/07/09 10:00 [entrez]
AID - 10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E [pii]
AID - 10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E [doi]
PST - ppublish
SO  - J Neurosci Res. 1999 Jul 1;57(1):13-22. doi:
      10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E.