PMID- 10396627
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190728
IS  - 0042-6989 (Print)
IS  - 0042-6989 (Linking)
VI  - 39
IP  - 15
DP  - 1999 Jul
TI  - Photoreceptor function of retinal transplants implicated by light-dark shift of
      S-antigen and rod transducin.
PG  - 2589-96
AB  - The aim was to demonstrate functional properties of transplanted histologically
      normal photoreceptors. Subretinal intact-sheet transplants of fetal E17-E20 rat
      retinas to light-damaged albino rat eyes were fixed in light or dark, 2 to 42
      weeks after transplantation, and stained immunohistochemically for certain
      phototransduction proteins. In light adapted transplants, transducin was
      predominantly found in inner segments of parallel-organized photoreceptors.
      Transducin shifted to the outer segments with dark-adaptation. S-antigen
      distribution was opposite to transducin. Rhodopsin distribution did not change.
      The shift of signal transduction proteins correlated to the light conditions
      indicates that normal phototransduction processes were established in
      photoreceptors of transplanted retinal sheets.
FAU - Seiler, M J
AU  - Seiler MJ
AD  - Department of Ophthalmology and Visual Sciences, University of Louisville School 
      of Medicine, KY 40202, USA. mjseil01@homer.louisville.edu
FAU - Aramant, R B
AU  - Aramant RB
FAU - Ball, S L
AU  - Ball SL
LA  - eng
GR  - EY08519/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Vision Res
JT  - Vision research
JID - 0417402
RN  - 0 (Arrestin)
RN  - 9009-81-8 (Rhodopsin)
RN  - EC 3.6.5.1 (Transducin)
SB  - IM
MH  - Adaptation, Ocular
MH  - Animals
MH  - Arrestin/biosynthesis
MH  - Dark Adaptation
MH  - Female
MH  - Immunohistochemistry
MH  - Photoreceptor Cells/metabolism/*transplantation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retina/radiation effects
MH  - Rhodopsin/biosynthesis
MH  - Transducin/biosynthesis
MH  - Vision, Ocular
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - S0042-6989(98)00326-5 [pii]
AID - 10.1016/s0042-6989(98)00326-5 [doi]
PST - ppublish
SO  - Vision Res. 1999 Jul;39(15):2589-96. doi: 10.1016/s0042-6989(98)00326-5.