PMID- 10395932
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1446
IP  - 1-2
DP  - 1999 Jul 7
TI  - Genomic organization, sequence and transcriptional regulation of the human CXCL
      11(1) gene.
PG  - 167-72
AB  - CXCL 11, encoded by the cDNA sequences designated beta-R1, H-174, or I-TAC, is a 
      CXC chemokine ligand for CXCR3 and assumed to be involved in inflammatory
      diseases characterized by the presence of activated T-cells. We here describe the
      genomic organization (four exons interrupted by three introns of 585, 98 and 230 
      bp) and sequence including 960 bp from the immediate 5'-upstream region of the
      human CXCL 11 gene. Within the promoter region, consensus sequences for
      regulatory elements (ISRE, GAS, NF-kappaB) important for cytokine-induced gene
      transcription were identified. The effect of (pro)inflammatory cytokines on CXCL 
      11 mRNA expression in monocytic cell lines (THP-1, U937) and primary cultures of 
      dermal fibroblasts and endothelial cells were examined using Northern blot
      analysis. For these cell types, IFN-gamma was a potent inducer of CXCL 11
      transcription, which was synergistically enhanced by TNF-alpha.
FAU - Tensen, C P
AU  - Tensen CP
AD  - Department of Dermatology, University Hospital Vrije Universiteit,
      Amsterdam/Leiden Institute for Immunology, 1081 HV, Amsterdam, Netherlands.
      cp.tensen@azvu.nl
FAU - Flier, J
AU  - Flier J
FAU - Rampersad, S S
AU  - Rampersad SS
FAU - Sampat-Sardjoepersad, S
AU  - Sampat-Sardjoepersad S
FAU - Scheper, R J
AU  - Scheper RJ
FAU - Boorsma, D M
AU  - Boorsma DM
FAU - Willemze, R
AU  - Willemze R
LA  - eng
SI  - GENBANK/Y15221
PT  - Journal Article
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (CXCL11 protein, human)
RN  - 0 (Chemokine CXCL11)
RN  - 0 (Chemokines, CXC)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Base Sequence
MH  - Cell Line
MH  - Chemokine CXCL11
MH  - Chemokines, CXC/chemistry/*genetics
MH  - Exons
MH  - Genomic Library
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/metabolism
MH  - Transcription, Genetic/drug effects
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - S0167478199000846 [pii]
AID - 10.1016/s0167-4781(99)00084-6 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Jul 7;1446(1-2):167-72. doi:
      10.1016/s0167-4781(99)00084-6.