PMID- 10395807
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20041117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 59
IP  - 1
DP  - 1999 Jul 1
TI  - Chromosomal localization of the loci responsible for dystrophic cardiac
      calcinosis in DBA/2 mice.
PG  - 105-7
AB  - Dystrophic cardiac calcinosis (DCC) occurs in certain inbred strains of mice,
      including DBA/2 and C3H/He, and is generally found as an incidental lesion in
      adult animals at necropsy. Preliminary genetic studies into the cause of DCC have
      been performed in DBA/2 mice and suggest that DCC is inherited as an autosomal
      recessive trait involving three or four unlinked genes. To investigate the
      genetics of DCC further, we produced myocardial cell death by freeze-thaw injury 
      to induce DCC. Experiments were conducted with three F1 hybrids made using three 
      inbred strains of mice (DBA/2J and C3H/HeJ, DCC-susceptible strains; C57BL/6J,
      DCC-resistant strain) to compare the genetic factors in the development of DCC.
      We found that DBA/2 and C3H/He mice share the same gene pattern(s) that is
      responsible for DCC. We determined by backcross linkage analysis in DBA/2 and
      C57BL/6 mice that at least one recessive locus is responsible for DCC. A
      haplotype analysis of the backcross data demonstrated that the recessive locus,
      designated dyscalc1, is located on Chromosome 7, 20.5 cM distal to the
      centromere. The likely candidate genes for dyscalc1 are discussed. Further
      understanding of the structure and function of these mutant genes will be
      beneficial in explaining the molecular pathogenesis of DCC.
CI  - Copyright 1999 Academic Press.
FAU - Brunnert, S R
AU  - Brunnert SR
AD  - College of Physicians and Surgeons, Columbia University, New York, New York
      10032, USA. srb3@columbia.edu
FAU - Shi, S
AU  - Shi S
FAU - Chang, B
AU  - Chang B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
SB  - IM
MH  - Animals
MH  - Calcinosis/*genetics/pathology
MH  - Cardiomyopathies/*genetics/pathology
MH  - Chromosome Mapping
MH  - Chromosomes/genetics
MH  - Crosses, Genetic
MH  - Female
MH  - Genes, Recessive/genetics
MH  - Genotype
MH  - Haplotypes
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - 10.1006/geno.1999.5862 [doi]
AID - S0888-7543(99)95862-7 [pii]
PST - ppublish
SO  - Genomics. 1999 Jul 1;59(1):105-7. doi: 10.1006/geno.1999.5862.