PMID- 10395806
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20191210
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 59
IP  - 1
DP  - 1999 Jul 1
TI  - Identification, sequence, and mapping of the mouse multiple PDZ domain protein
      gene, Mpdz.
PG  - 102-4
AB  - The PDZ domain gained its name from the three proteins that were first seen to
      have homology by virtue of these domains, the mammalian postsynaptic density
      protein, PSD-95, the Drosophila discs-large septate junction protein, DLG, and
      the mammalian epithelial tight-junction protein zona occludens, ZO-1. Over 50 PDZ
      domain-containing genes have been recognized so far from almost any organism
      subjected to sequencing, including mammals, nematodes, yeast, plants, and
      bacteria. The domain consists of an approximately 90-amino-acid-residue unit,
      which is often repeated in the protein. The majority of residues form a conserved
      spatial structure while a few amino acids in critical positions confer protein
      binding specificity. A subgroup of PDZ domains have been shown to recognize a
      short carboxy-terminal amino acid motif, T/SXV (Ser/Thr-X-Val-COO-), where X is
      any amino acid. We have identified and completely sequenced a gene, Mpdz, that
      encodes a mouse protein containing 13 such domains. We have also mapped the gene 
      to a series of overlapping deletions on mouse chromosome 4 and can therefore
      determine that its function is not essential for embryonic development or
      neonatal survival.
CI  - Copyright 1999 Academic Press.
FAU - Simpson, E H
AU  - Simpson EH
AD  - MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4
      2XU, United Kingdom.
FAU - Suffolk, R
AU  - Suffolk R
FAU - Jackson, I J
AU  - Jackson IJ
LA  - eng
SI  - GENBANK/AJ131869
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mpdz protein, mouse)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Carrier Proteins/*genetics
MH  - Chromosome Mapping
MH  - DNA/chemistry/*genetics
MH  - Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - 10.1006/geno.1999.5853 [doi]
AID - S0888-7543(99)95853-6 [pii]
PST - ppublish
SO  - Genomics. 1999 Jul 1;59(1):102-4. doi: 10.1006/geno.1999.5853.