PMID- 10395804
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20041117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 59
IP  - 1
DP  - 1999 Jul 1
TI  - Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the
      eighth human DNA polymerase.
PG  - 90-6
AB  - We have cloned the cDNA for the eighth human DNA polymerase, DNA polymerase
      θ. The human cDNA encodes a putative DNA polymerase of 1762 amino acids
      with a calculated molecular mass of 198 kDa. The derived protein sequence is
      homologous to the Drosophila melanogaster mus308 protein product, a putative DNA 
      polymerase-helicase involved in repair of interstrand crosslinks. The C-terminal 
      region contains the canonical DNA polymerase motifs A, B, and C found in the
      family A type of DNA polymerases, which includes Escherichia coli polymerase I.
      The N-terminal region contains a putative ATP binding domain but not motifs for a
      helicase. The gene was mapped by radiation hybrid analysis to chromosome 3q
      within an interval flanked by proximal marker D3S1303 and distal marker D3S3576
      and, based on proximity to a gene that has been mapped cytogenetically, within
      band 3q13.31.
CI  - Copyright 1999 Academic Press.
FAU - Sharief, F S
AU  - Sharief FS
AD  - Laboratory of Molecular Genetics, National Institute of Environmental Health
      Sciences, Research Triangle Park, North Carolina 27709, USA.
FAU - Vojta, P J
AU  - Vojta PJ
FAU - Ropp, P A
AU  - Ropp PA
FAU - Copeland, W C
AU  - Copeland WC
LA  - eng
SI  - GENBANK/AF052573
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (Genetic Markers)
RN  - EC 2.7.7.- (DNA polymerase theta)
RN  - EC 2.7.7.7 (DNA-Directed DNA Polymerase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/genetics
MH  - DNA-Directed DNA Polymerase/*genetics
MH  - Genetic Markers
MH  - HeLa Cells
MH  - Humans
MH  - Hybrid Cells
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tumor Cells, Cultured
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - 10.1006/geno.1999.5843 [doi]
AID - S0888-7543(99)95843-3 [pii]
PST - ppublish
SO  - Genomics. 1999 Jul 1;59(1):90-6. doi: 10.1006/geno.1999.5843.