PMID- 10395802
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20170922
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 59
IP  - 1
DP  - 1999 Jul 1
TI  - Characterization of a novel chromo domain gene in xp22.3 with homology to
      Drosophila msl-3.
PG  - 77-84
AB  - The Drosophila male-specific lethal (MSL) genes regulate transcription from the
      male X chromosome in a dosage compensation pathway that equalizes X-linked gene
      expression in males and females. The members of this gene family, including
      msl-1, msl-2, msl-3, mle, and mof, encode proteins with no sequence homology.
      However, mutations in each of these genes produce a similar phenotype:
      sex-specific lethality of male embryos caused by the failure of mutants to
      increase transcription from the single male X chromosome. The MSL gene products
      assemble into a multiprotein transcriptional activation complex at hundreds of
      sites along the chromatin of the X chromosome. Here we report the isolation and
      characterization of a human gene, named MSL3L1, that encodes a protein with
      significant homology to Drosophila MSL-3 in three distinct regions, including two
      putative chromo domains. MSL3L1 was identified by database queries with genomic
      sequence from BAC GS-590J6 (GenBank AC0004554) in Xp22.3 and was evaluated as a
      candidate gene for several developmental disorders mapping to this region,
      including OFD1 and SED tarda, as well as Aicardi syndrome and Goltz syndrome.
CI  - Copyright 1999 Academic Press.
FAU - Prakash, S K
AU  - Prakash SK
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 
      Texas 77030, USA.
FAU - Van den Veyver, I B
AU  - Van den Veyver IB
FAU - Franco, B
AU  - Franco B
FAU - Volta, M
AU  - Volta M
FAU - Ballabio, A
AU  - Ballabio A
FAU - Zoghbi, H Y
AU  - Zoghbi HY
LA  - eng
SI  - GENBANK/AF117065
SI  - GENBANK/AF117066
GR  - TGM06S01/Telethon/Italy
GR  - TGM97000/Telethon/Italy
GR  - K08-HD01171/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Chromatin)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (MSL3 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 164205-99-6 (msl-3 protein, Drosophila)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Chromatin/*metabolism
MH  - Chromosomal Proteins, Non-Histone/*genetics/metabolism
MH  - Chromosome Mapping
MH  - DNA/chemistry/genetics
MH  - DNA Mutational Analysis
MH  - DNA, Complementary/chemistry/genetics
MH  - Dosage Compensation, Genetic
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Exons
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Genes/genetics
MH  - Humans
MH  - Introns
MH  - Male
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Transcription Factors/*genetics
MH  - X Chromosome/*genetics
EDAT- 1999/07/09 00:00
MHDA- 1999/07/09 00:01
CRDT- 1999/07/09 00:00
PHST- 1999/07/09 00:00 [pubmed]
PHST- 1999/07/09 00:01 [medline]
PHST- 1999/07/09 00:00 [entrez]
AID - 10.1006/geno.1999.5844 [doi]
AID - S0888-7543(99)95844-5 [pii]
PST - ppublish
SO  - Genomics. 1999 Jul 1;59(1):77-84. doi: 10.1006/geno.1999.5844.