PMID- 10395086
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20190818
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 195
IP  - 1-2
DP  - 1999 May
TI  - The DHHC domain: a new highly conserved cysteine-rich motif.
PG  - 219-26
AB  - A unique clone from a human pancreatic cDNA library was isolated and sequenced.
      Examination of the deduced polypeptide sequence of the clone showed a new form of
      cysteine-rich domain that included a region with the form of a Cys4
      zinc-finger-like metal binding site followed by a complex Cys-His region.
      Searches of the Swiss-Protein data bank found a similar 48-residue domain in
      fifteen open reading frames deduced from A. thaliana, C. elegans, S. cerevisiae
      and S. pombe genomic sequences. The high degree of conservation of this domain
      (13 absolutely conserved and 17 highly conserved positions) suggests that it has 
      an important function in the cell, possibly related to protein-protein or
      protein-DNA interactions. The gene recognized by the clone is is localized to
      human chromosome 16, and is conserved in vertebrates. The 2 Kb message is
      expressed in various human fetal and adult tissues. An antibody made to a peptide
      sequence of the deduced protein showed reactivity in immunoblots of monkey lung
      and retinal subcellular fractions and immunohistochemically in late fetal mouse
      tissues and a limited number of adult mouse tissues, including pancreatic islets,
      Leydig cells of the testis, and the plexiform layers of the retina.
FAU - Putilina, T
AU  - Putilina T
AD  - Laboratory of Retinal Cell and Molecular Biology, National Eye Institute,
      National Institutes of Health, Bethesda, MD, USA.
FAU - Wong, P
AU  - Wong P
FAU - Gentleman, S
AU  - Gentleman S
LA  - eng
SI  - GENBANK/U90653
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Fungal Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Plant Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 130704-09-5 (cysteine-rich protein, mammalian)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (ZDHHC1 protein, human)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Acyltransferases
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cattle
MH  - Chickens
MH  - Chromosomes, Human, Pair 16
MH  - *Conserved Sequence
MH  - Cysteine/*metabolism
MH  - Fungal Proteins
MH  - Haplorhini
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Nuclear Proteins
MH  - Pancreas/chemistry
MH  - Plant Proteins
MH  - *Proteins
MH  - Proto-Oncogene Proteins c-myc/chemistry/genetics/*isolation & purification
MH  - Rabbits
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Zinc Fingers/genetics
EDAT- 1999/07/08 00:00
MHDA- 1999/07/08 00:01
CRDT- 1999/07/08 00:00
PHST- 1999/07/08 00:00 [pubmed]
PHST- 1999/07/08 00:01 [medline]
PHST- 1999/07/08 00:00 [entrez]
AID - 10.1023/a:1006932522197 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 1999 May;195(1-2):219-26. doi: 10.1023/a:1006932522197.