PMID- 10394128
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20171101
IS  - 0030-2414 (Print)
IS  - 0030-2414 (Linking)
VI  - 57
IP  - 1
DP  - 1999 Jul
TI  - Sialyl Tn is a frequently expressed antigen in colorectal cancer: No correlation 
      with patient prognosis.
PG  - 70-6
AB  - Immunohistochemical expression of sialyl Tn antigen (STn), previously claimed to 
      be a prognostic factor in colorectal cancer, was evaluated in 239 patients with
      colorectal adenocarcinoma. Formalin-fixed, paraffin-embedded specimens were
      stained with the monoclonal antibody C1282. STn immunoreactivity was seen in 189 
      of 239 tumors (79%). There was no significant correlation between STn
      immunoreactivity and Dukes stage, tumor location, histological type or gender.
      However, STn was significantly more often expressed in younger patients. There
      was so significant difference in survival between STn-negative patients (median
      survival 68 months) and STn-positive patients (median survival 79 months). In a
      Cox multivariate analysis, Dukes stage was the strongest predictor of outcome,
      followed by the age of the patient, whereas STn did not provide any prognostic
      information.
FAU - Lundin, M
AU  - Lundin M
AD  - Second Department of Surgery, University of Helsinki, Finland.
FAU - Nordling, S
AU  - Nordling S
FAU - Roberts, P J
AU  - Roberts PJ
FAU - Lundin, J
AU  - Lundin J
FAU - Carpelan-Holmstrom, M
AU  - Carpelan-Holmstrom M
FAU - von Boguslawsky, K
AU  - von Boguslawsky K
FAU - Haglund, C
AU  - Haglund C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Antigens, Tumor-Associated, Carbohydrate)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (sialosyl-Tn antigen)
SB  - IM
MH  - Adenocarcinoma/*immunology/pathology
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Tumor-Associated, Carbohydrate/*analysis
MH  - Biomarkers, Tumor/*analysis
MH  - Colorectal Neoplasms/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Survival Analysis
EDAT- 1999/07/08 00:00
MHDA- 1999/07/08 00:01
CRDT- 1999/07/08 00:00
PHST- 1999/07/08 00:00 [pubmed]
PHST- 1999/07/08 00:01 [medline]
PHST- 1999/07/08 00:00 [entrez]
AID - 12003 [pii]
AID - 10.1159/000012003 [doi]
PST - ppublish
SO  - Oncology. 1999 Jul;57(1):70-6. doi: 10.1159/000012003.