PMID- 10393857
OWN - NLM
STAT- MEDLINE
DCOM- 19990726
LR  - 20190607
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 155
IP  - 1
DP  - 1999 Jul
TI  - Interleukin-18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr
      virus-induced infectious mononucleosis and posttransplant lymphoproliferative
      disease.
PG  - 257-65
AB  - T cell immunodeficiency plays an important role in the pathogenesis of
      posttransplant lymphoproliferative disease (PTLD) by permitting the unbridled
      expansion of Epstein-Barr virus (EBV)-infected B lymphocytes. However, factors
      other than T cell function may contribute to PTLD pathogenesis because PTLD
      infrequently develops even in the context of severe T cell immunodeficiency, and 
      athymic mice that are T-cell-immunodeficient can reject EBV-immortalized cells.
      Here we report that PTLD tissues express significantly lower levels of IL-18,
      interferon-gamma (IFN-gamma), Mig, and RANTES compared to lymphoid tissues
      diagnosed with acute EBV-induced infectious mononucleosis, as assessed by
      semiquantitative RT-PCR analysis. Other cytokines and chemokines are expressed at
      similar levels. Immunohistochemistry confirmed that PTLD tissues contain less
      IL-18 and Mig protein than tissues with infectious mononucleosis. IL-18,
      primarily a monocyte product, promotes the secretion of IFN-gamma, which
      stimulates Mig and RANTES expression. Both IL-18 and Mig display antitumor
      activity in mice involving inhibition of angiogenesis. These results document
      greater expression of IL-18, IFN-gamma, Mig, and RANTES in lymphoid tissues with 
      acute EBV-induced infectious mononucleosis compared to tissues with PTLD and
      raise the possibility that these mediators participate in critical host responses
      to EBV infection.
FAU - Setsuda, J
AU  - Setsuda J
AD  - Laboratory of Pathology,* Hematopathology Section, National Cancer Institute,
      National Institutes of Health, Bethesda, Maryland, USA.
FAU - Teruya-Feldstein, J
AU  - Teruya-Feldstein J
FAU - Harris, N L
AU  - Harris NL
FAU - Ferry, J A
AU  - Ferry JA
FAU - Sorbara, L
AU  - Sorbara L
FAU - Gupta, G
AU  - Gupta G
FAU - Jaffe, E S
AU  - Jaffe ES
FAU - Tosato, G
AU  - Tosato G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-18)
SB  - AIM
SB  - IM
SB  - X
MH  - Adolescent
MH  - Adult
MH  - Chemokine CCL5/metabolism
MH  - Chemokine CXCL10
MH  - Chemokine CXCL9
MH  - Chemokines, CXC/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Epstein-Barr Virus Infections/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infectious Mononucleosis/*metabolism
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Interleukin-18/*metabolism
MH  - Lymphoproliferative Disorders/etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Organ Transplantation
MH  - Postoperative Complications
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC1866647
EDAT- 1999/07/08 00:00
MHDA- 1999/07/08 00:01
CRDT- 1999/07/08 00:00
PHST- 1999/07/08 00:00 [pubmed]
PHST- 1999/07/08 00:01 [medline]
PHST- 1999/07/08 00:00 [entrez]
AID - S0002-9440(10)65119-X [pii]
AID - 10.1016/s0002-9440(10)65119-x [doi]
PST - ppublish
SO  - Am J Pathol. 1999 Jul;155(1):257-65. doi: 10.1016/s0002-9440(10)65119-x.