PMID- 10393528
OWN - NLM
STAT- MEDLINE
DCOM- 19990722
LR  - 20180213
IS  - 1010-4283 (Print)
IS  - 1010-4283 (Linking)
VI  - 20
IP  - 4
DP  - 1999 Jul-Aug
TI  - Cloning and sequencing of human oncodevelopmental soluble placental tissue
      protein 17 (PP17): homology with adipophilin and the mouse adipose
      differentiation-related protein.
PG  - 184-92
AB  - Using a monospecific anti-PP17 antiserum, we detected 4 different
      molecular-weight PP17 immunoreactive proteins (31,500 kD PP17a, 48, 000 kD PP17b,
      60,900 kD PP17c and 74,000 kD PP17d) in different normal adult and fetal human
      tissues, and in term placenta, by chemiluminescence Western blot analysis. These 
      proteins are overexpressed in cervix carcinoma tissue. Furthermore, increased
      amounts of PP17b are secreted into the circulation in cervix carcinoma patients; 
      after radical surgery, PP17b serum levels are decreased, and the protein probably
      has an oncodevelopmental significance. cDNAs were isolated from a human placental
      cDNA library with the monospecific anti-PP17 antiserum. Sequence analysis of the 
      clones showed that they encode for the 251 residue long PP17a variant, which is
      identical to the previously isolated and characterized PP17 antigen described in 
      1983. An alignment search of the protein databank showed that PP17a is homologous
      to human adipophilin and mouse adipose differentiation-related protein. PP17c
      turned out to be a dimer of PP17a, while PP17b and PP17d immunoreactive proteins 
      recently detected on Western blots require further investigations.
FAU - Than, N G
AU  - Than NG
AD  - Institute of Biochemistry, University Medical School of Pecs, Hungary.
FAU - Sumegi, B
AU  - Sumegi B
FAU - Than, G N
AU  - Than GN
FAU - Kispal, G
AU  - Kispal G
FAU - Bohn, H
AU  - Bohn H
LA  - eng
SI  - GENBANK/AF051315
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (PLIN2 protein, human)
RN  - 0 (PLIN3 protein, human)
RN  - 0 (Peptides)
RN  - 0 (Perilipin-2)
RN  - 0 (Perilipin-3)
RN  - 0 (Plin2 protein, mouse)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (Vesicular Transport Proteins)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Western
MH  - *Carrier Proteins
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry
MH  - *DNA-Binding Proteins
MH  - Female
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Luminescent Measurements
MH  - Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Peptides/*chemistry
MH  - Perilipin-2
MH  - Perilipin-3
MH  - Pregnancy Proteins/*chemistry/genetics
MH  - Sequence Homology, Amino Acid
MH  - Uterine Cervical Neoplasms/blood
MH  - Vesicular Transport Proteins
EDAT- 1999/07/07 00:00
MHDA- 1999/07/07 00:01
CRDT- 1999/07/07 00:00
PHST- 1999/07/07 00:00 [pubmed]
PHST- 1999/07/07 00:01 [medline]
PHST- 1999/07/07 00:00 [entrez]
AID - 30062 [pii]
AID - 10.1159/000030062 [doi]
PST - ppublish
SO  - Tumour Biol. 1999 Jul-Aug;20(4):184-92. doi: 10.1159/000030062.