PMID- 10393337
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20190513
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 126
IP  - 1
DP  - 1999 Jul
TI  - A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem
      LIM-domains.
PG  - 180-7
AB  - LIM-homeodomain (LHX) transcription factors play critical roles in cell fate
      determination during development, in particular, in CNS. The transcriptional
      activity of several LHX proteins is postulated to be regulated by interaction
      with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX
      molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6
      molecule. The Lhx6.1 transcript is found in several restricted regions in the
      developing CNS, mostly within the embryonic forebrain. We further show that
      Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional
      regulation of Lhx6.1 by Ldb1.
FAU - Kimura, N
AU  - Kimura N
AD  - Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical
      and Dental University, Tokyo, 101-0062, Japan.
FAU - Ueno, M
AU  - Ueno M
FAU - Nakashima, K
AU  - Nakashima K
FAU - Taga, T
AU  - Taga T
LA  - eng
SI  - GENBANK/AB031039
SI  - GENBANK/AB031040
SI  - GENBANK/AB031041
SI  - GENBANK/AB031042
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LDB1 protein, human)
RN  - 0 (LHX6 protein, human)
RN  - 0 (LHX6 protein, mouse)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Ldb1 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/embryology/growth & development/*metabolism
MH  - COS Cells/metabolism
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/*genetics/*metabolism
MH  - Humans
MH  - LIM Domain Proteins
MH  - LIM-Homeodomain Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Organ Specificity
MH  - Recombinant Proteins/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors
MH  - Transcription, Genetic
EDAT- 1999/07/07 00:00
MHDA- 1999/07/07 00:01
CRDT- 1999/07/07 00:00
PHST- 1999/07/07 00:00 [pubmed]
PHST- 1999/07/07 00:01 [medline]
PHST- 1999/07/07 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a022420 [doi]
PST - ppublish
SO  - J Biochem. 1999 Jul;126(1):180-7. doi: 10.1093/oxfordjournals.jbchem.a022420.