PMID- 10393115
OWN - NLM
STAT- MEDLINE
DCOM- 19990921
LR  - 20171116
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 15
DP  - 1999 Aug
TI  - Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular
      respecification within the basal telencephalon: evidence for a transformation of 
      the pallidum into the striatum.
PG  - 3359-70
AB  - The telencephalon is organized into distinct longitudinal domains: the cerebral
      cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal
      region (striatum) and a ventral region (pallidum). Within the telencephalon, the 
      anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in
      Nkx2.1 function does not form pallidal structures, lacks basal forebrain
      TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of
      cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum
      through the striatum and into the cortex. We present evidence that these
      phenotypes result from a ventral-to-dorsal transformation of the pallidal
      primordium into a striatal-like anlage.
FAU - Sussel, L
AU  - Sussel L
AD  - Center for Neurobiology and Psychiatry, Department of Psychiatry and University
      of California at San Francisco, CA 94143-0984, USA.
FAU - Marin, O
AU  - Marin O
FAU - Kimura, S
AU  - Kimura S
FAU - Rubenstein, J L
AU  - Rubenstein JL
LA  - eng
GR  - K02 MH01046-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (DNA Primers)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nkx2-1 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (Thyroid Nuclear Factor 1)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Body Patterning/genetics/physiology
MH  - Cell Movement/genetics
MH  - Corpus Striatum/embryology
MH  - DNA Primers/genetics
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - *Genes, Homeobox
MH  - Globus Pallidus/embryology
MH  - Hedgehog Proteins
MH  - Homeodomain Proteins/genetics/physiology
MH  - Interneurons/cytology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - Nuclear Proteins/*genetics/physiology
MH  - Phenotype
MH  - Pregnancy
MH  - Proteins/genetics
MH  - Telencephalon/*embryology
MH  - Thyroid Nuclear Factor 1
MH  - *Trans-Activators
MH  - Transcription Factors/*genetics/physiology
EDAT- 1999/07/07 00:00
MHDA- 1999/07/07 00:01
CRDT- 1999/07/07 00:00
PHST- 1999/07/07 00:00 [pubmed]
PHST- 1999/07/07 00:01 [medline]
PHST- 1999/07/07 00:00 [entrez]
PST - ppublish
SO  - Development. 1999 Aug;126(15):3359-70.