PMID- 10393083
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20181113
IS  - 0264-6021 (Print)
IS  - 0264-6021 (Linking)
VI  - 341 ( Pt 2)
DP  - 1999 Jul 15
TI  - Cloning and characterization of gp36, a human mucin-type glycoprotein
      preferentially expressed in vascular endothelium.
PG  - 277-84
AB  - A mucin-type glycoprotein has been described in murine, rat and canine tissues as
      a differentiation antigen and influenza-virus receptor. We have cloned a cDNA
      from human placenta RNA encoding the corresponding human protein, a type-I
      integral membrane protein of 162 amino acids. Madin-Darby canine kidney cells
      transfected with the cDNA clone directed the cell-surface expression of a 36-kDa 
      O-glycosylated sialoglycoprotein, gp36, and two minor isoforms of 28 and 70 kDa. 
      gp36 has a broad tissue distribution with strong expression in lung, placenta and
      skeletal muscle, as shown by PCR screening of different cDNA libraries.
      Immunohistochemical detection of gp36 in cryo-sections of human placenta, kidney,
      lung and nasal polyps showed that the glycoprotein is expressed at the apical
      plasma membrane of vascular endothelial cells. Expression of gp36 was not
      restricted to endothelial cells, as alveolar epithelial cells were found to
      express gp36 as well.
FAU - Zimmer, G
AU  - Zimmer G
AD  - Institut fur Virologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D-30559
      Hannover, Germany.
FAU - Oeffner, F
AU  - Oeffner F
FAU - Von Messling, V
AU  - Von Messling V
FAU - Tschernig, T
AU  - Tschernig T
FAU - Groness, H J
AU  - Groness HJ
FAU - Klenk, H D
AU  - Klenk HD
FAU - Herrler, G
AU  - Herrler G
LA  - eng
SI  - GENBANK/AJ225022
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Mucins)
RN  - 0 (PDPN protein, human)
RN  - 0 (Protein Isoforms)
RN  - 0 (Sialoglycoproteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Dogs
MH  - Endothelium, Vascular/*metabolism
MH  - Humans
MH  - Membrane Glycoproteins
MH  - Molecular Sequence Data
MH  - Mucins/biosynthesis/*genetics
MH  - Protein Isoforms/biosynthesis/genetics
MH  - Rats
MH  - Sequence Alignment
MH  - Sialoglycoproteins/biosynthesis/*genetics
PMC - PMC1220357
EDAT- 1999/07/07 00:00
MHDA- 1999/07/07 00:01
CRDT- 1999/07/07 00:00
PHST- 1999/07/07 00:00 [pubmed]
PHST- 1999/07/07 00:01 [medline]
PHST- 1999/07/07 00:00 [entrez]
PST - ppublish
SO  - Biochem J. 1999 Jul 15;341 ( Pt 2):277-84.