PMID- 10391246
OWN - NLM
STAT- MEDLINE
DCOM- 19990721
LR  - 20111102
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 399
IP  - 6738
DP  - 1999 Jun 24
TI  - MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in
      Caenorhabditis elegans.
PG  - 793-7
AB  - The signalling protein Wnt regulates transcription factors containing
      high-mobility-group (HMG) domains to direct decisions on cell fate during animal 
      development. In Caenorhabditis elegans, the HMG-domain-containing repressor POP-1
      distinguishes the fates of anterior daughter cells from their posterior sisters
      throughout development, and Wnt signalling downregulates POP-1 activity in one
      posterior daughter cell called E. Here we show that the genes mom-4 and lit-1 are
      also required to downregulate POP-1, not only in E but also in other posterior
      daughter cells. Consistent with action in a common pathway, mom-4 and lit-1
      exhibit similar mutant phenotypes and encode components of the mitogen-activated 
      protein kinase (MAPK) pathway that are homologous to vertebrate
      transforming-growth-factor-beta-activated kinase (TAK1) and NEMO-like kinase
      (NLK), respectively. Furthermore, MOM-4 and TAK1 bind related proteins that
      promote their kinase activities. We conclude that a MAPK-related pathway
      cooperates with Wnt signal transduction to downregulate POP-1 activity. These
      functions are likely to be conserved in vertebrates, as TAK1 and NLK can
      downregulate HMG-domain-containing proteins related to POP-1.
FAU - Meneghini, M D
AU  - Meneghini MD
AD  - Institute of Molecular Biology, University of Oregon, Eugene 97403, USA.
FAU - Ishitani, T
AU  - Ishitani T
FAU - Carter, J C
AU  - Carter JC
FAU - Hisamoto, N
AU  - Hisamoto N
FAU - Ninomiya-Tsuji, J
AU  - Ninomiya-Tsuji J
FAU - Thorpe, C J
AU  - Thorpe CJ
FAU - Hamill, D R
AU  - Hamill DR
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Bowerman, B
AU  - Bowerman B
LA  - eng
SI  - GENBANK/AF145375
SI  - GENBANK/AF145376
SI  - GENBANK/AF145377
GR  - R01/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (KCNQ1OT1 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TAB1 protein, MAPKKK activator, vertebrate)
RN  - 0 (TAB1 protein, human)
RN  - 0 (Wnt Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (mom-4 protein, C elegans)
RN  - 0 (pop-1 protein, C elegans)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (NLK protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (lit-1 protein, C elegans)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP kinase kinase kinase 7)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans/enzymology/*genetics/metabolism
MH  - *Caenorhabditis elegans Proteins
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Carrier Proteins/genetics/metabolism
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics
MH  - *Down-Regulation
MH  - Enzyme Activation
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Helminth
MH  - High Mobility Group Proteins/*genetics
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - *JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase 4
MH  - *MAP Kinase Kinase Kinases
MH  - Membrane Proteins/genetics/metabolism
MH  - *Mitogen-Activated Protein Kinase Kinases
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Potassium Channels, Voltage-Gated
MH  - Protein Kinases/metabolism
MH  - Protein-Serine-Threonine Kinases/chemistry/genetics/metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Wnt Proteins
MH  - *Zebrafish Proteins
EDAT- 1999/07/03 10:00
MHDA- 2001/03/23 10:01
CRDT- 1999/07/03 10:00
PHST- 1999/07/03 10:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/07/03 10:00 [entrez]
AID - 10.1038/21666 [doi]
PST - ppublish
SO  - Nature. 1999 Jun 24;399(6738):793-7. doi: 10.1038/21666.