PMID- 10391090
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190513
IS  - 0910-5050 (Print)
IS  - 0910-5050 (Linking)
VI  - 90
IP  - 5
DP  - 1999 May
TI  - Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent
      mutations in endometrioid carcinomas.
PG  - 510-5
AB  - To investigate the contribution of the beta-catenin gene to the development of
      ovarian carcinomas, mutational analysis of exon 3 of the beta-catenin gene was
      conducted. We analyzed 61 primary ovarian carcinomas, consisting of 49
      non-endometrioid-type and 12 endometrioid-type tumors, for genetic alteration of 
      the beta-catenin gene. Five carcinomas showed beta-catenin mutations (S37C, T41I,
      T41A), including 4 (33%) of 12 endometrioid-type tumors and 1 (14%) of 7
      mucinous-type tumors. All of these mutations altered at the serine/threonine
      residues that are potential sites of GSK3-beta phosphorylation. We detected no
      carcinomas with interstitial deletion involving exon 3 of beta-catenin.
      Furthermore, we immunohistochemically studied 27 of the 61 ovarian carcinomas.
      Both nuclear and cytoplasmic beta-catenin expressions were demonstrated in 4 of
      the 27 ovarian carcinomas for which tissue samples were available for
      examination. All 4 cases exhibited mutations in exon 3 of beta-catenin, including
      a mucinous carcinoma. Our results suggested that beta-catenin gene mutation at
      potential GSK3-beta phosphorylation sites results in accumulation of beta-catenin
      protein within the cells and its translocation to nuclei. Accumulated
      beta-catenin protein may be involved in the development of endometrioid-type
      ovarian carcinomas, and some mucinous-type ovarian carcinomas.
FAU - Sagae, S
AU  - Sagae S
AD  - Department of Obstetrics and Gynecology, Cancer Research Institute, Sapporo
      Medical University School of Medicine, Hokkaido. sagaes@sapmed.ac.jp
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Nishioka, Y
AU  - Nishioka Y
FAU - Sugimura, M
AU  - Sugimura M
FAU - Ishioka, S
AU  - Ishioka S
FAU - Nagata, M
AU  - Nagata M
FAU - Terasawa, K
AU  - Terasawa K
FAU - Tokino, T
AU  - Tokino T
FAU - Kudo, R
AU  - Kudo R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Adult
MH  - Carcinoma, Endometrioid/*genetics
MH  - Cytoskeletal Proteins/*genetics
MH  - *DNA Mutational Analysis
MH  - Female
MH  - Genome, Human
MH  - Humans
MH  - Immunohistochemistry
MH  - Japan
MH  - Middle Aged
MH  - Ovarian Neoplasms/*genetics
MH  - *Trans-Activators
MH  - beta Catenin
PMC - PMC5926097
EDAT- 1999/07/03 00:00
MHDA- 1999/07/03 00:01
CRDT- 1999/07/03 00:00
PHST- 1999/07/03 00:00 [pubmed]
PHST- 1999/07/03 00:01 [medline]
PHST- 1999/07/03 00:00 [entrez]
AID - S0910505099801112 [pii]
AID - 10.1111/j.1349-7006.1999.tb00777.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1999 May;90(5):510-5. doi: 10.1111/j.1349-7006.1999.tb00777.x.