PMID- 10389856
OWN - NLM
STAT- MEDLINE
DCOM- 19990722
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 48
IP  - 7
DP  - 1999 Jul
TI  - The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific 
      glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic
      Japanese population.
PG  - 1469-72
AB  - A newly identified 3'-untranslated region (UTR) polymorphism of the gene for
      skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1
      (PPP1R3) was associated with insulin resistance and type 2 diabetes in Pima
      Indians (Xia J, Scherers W, Cohen PTW, Majer M, Xi T, Norman RA, Knowler WC,
      Bogardus C, Prochazka M: A common variant in PP1R3 associated with insulin
      resistance and type 2 diabetes. Diabetes 47:1519-1524, 1998). Thus, we
      investigated the frequency of polymorphism of the adenine- and thymine-rich
      element (ARE-1 and its variant ARE-2) in 426 Japanese type 2 diabetic and 380
      nondiabetic subjects using a polymerase chain reaction (PCR)-restriction enzyme
      fragment length polymorphism (RFLP) method. The allele frequency of the ARE-2
      variant in diabetic subjects was higher than that in nondiabetic subjects (0.34
      vs. 0.29; P < 0.05), even though its frequency in Japanese subjects was lower (P 
      < 0.001) than the reported value in Pima Indians (0.56). An aspartate
      polymorphism at codon 905 was 100% coupled to the ARE-2 allele, and its allele
      frequency was higher also in diabetic subjects. Although a serine substitution at
      codon 883 was partially linked with the ARE-2 allele, there was no difference
      between diabetic and nondiabetic subjects. These results indicate that the
      frequency of polymorphism of the PPP1R3 gene (ARE-2 and Asp905) is different
      between two ethnic groups and is increased in Japanese people with type 2
      diabetes, suggesting that these variants may be a possible marker for searching
      for diabetogenic genes.
FAU - Maegawa, H
AU  - Maegawa H
AD  - Third Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
FAU - Shi, K
AU  - Shi K
FAU - Hidaka, H
AU  - Hidaka H
FAU - Iwai, N
AU  - Iwai N
FAU - Nishio, Y
AU  - Nishio Y
FAU - Egawa, K
AU  - Egawa K
FAU - Kojima, H
AU  - Kojima H
FAU - Haneda, M
AU  - Haneda M
FAU - Yasuda, H
AU  - Yasuda H
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Kinoshita, M
AU  - Kinoshita M
FAU - Kikkawa, R
AU  - Kikkawa R
FAU - Kashiwagi, A
AU  - Kashiwagi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (3' Untranslated Regions)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - EC 3.1.3.- (PPP1R3A protein, human)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
RN  - EC 3.1.3.16 (Protein Phosphatase 1)
SB  - AIM
SB  - IM
MH  - *3' Untranslated Regions
MH  - Alleles
MH  - Aspartic Acid
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Phosphoprotein Phosphatases/chemistry/*genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Protein Phosphatase 1
EDAT- 1999/07/02 00:00
MHDA- 1999/07/02 00:01
CRDT- 1999/07/02 00:00
PHST- 1999/07/02 00:00 [pubmed]
PHST- 1999/07/02 00:01 [medline]
PHST- 1999/07/02 00:00 [entrez]
AID - 10.2337/diabetes.48.7.1469 [doi]
PST - ppublish
SO  - Diabetes. 1999 Jul;48(7):1469-72. doi: 10.2337/diabetes.48.7.1469.