PMID- 10389750
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 82
IP  - 2
DP  - 1999 Jul 19
TI  - Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular
      carcinomas in Jiang-su province of China.
PG  - 187-90
AB  - Environmental carcinogens often induce specific mutations in the p53 gene,
      apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related
      hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has
      received a great deal of attention, but its significance is still controversial. 
      To clarify this problem, we analyzed the p53-mutational status of HCCs in
      Jiang-su province in China, where AFB1 contamination of the staple food
      significantly differs between the northern and southern parts (prominent only in 
      the latter), while other conditions are quite similar. Background liver status
      and mutations in exons 5 to 8 of p53 in a total of 31 cases were divided
      approximately equally between the 2 areas. In all, 15 tumors exhibited a total of
      17 mutations in the p53 gene; 9 cases from the southern part of the province had 
      the hot-spot mutation at codon 249 (9/16, 56%), but only one case from the
      northern part (1/15, 8%). These results suggest that AFB1 contamination may
      correlate with codon-249 mutations in HCC.
FAU - Shimizu, Y
AU  - Shimizu Y
AD  - Department of Pathology, Graduate School of Medicine, University of Tokyo, Japan.
FAU - Zhu, J J
AU  - Zhu JJ
FAU - Han, F
AU  - Han F
FAU - Ishikawa, T
AU  - Ishikawa T
FAU - Oda, H
AU  - Oda H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (DNA, Neoplasm)
RN  - 9N2N2Y55MH (Aflatoxin B1)
SB  - IM
MH  - Adult
MH  - Aflatoxin B1/adverse effects
MH  - Aged
MH  - Carcinoma, Hepatocellular/chemically induced/epidemiology/*genetics
MH  - China/epidemiology
MH  - Cluster Analysis
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Food Contamination
MH  - *Genes, p53
MH  - Humans
MH  - Liver Neoplasms/chemically induced/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Retrospective Studies
EDAT- 1999/07/02 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/07/02 10:00
PHST- 1999/07/02 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/07/02 10:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19990719)82:2<187::AID-IJC6>3.0.CO;2-1 [pii]
AID - 10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc6>3.0.co;2-1 [doi]
PST - ppublish
SO  - Int J Cancer. 1999 Jul 19;82(2):187-90. doi:
      10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc6>3.0.co;2-1.