PMID- 10388558
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20131121
IS  - 0022-2836 (Print)
IS  - 0022-2836 (Linking)
VI  - 290
IP  - 1
DP  - 1999 Jul 2
TI  - Comparative sequence analysis of the complete human sarcomeric myosin heavy chain
      family: implications for functional diversity.
PG  - 61-75
AB  - The conventional myosin motor proteins that drive mammalian skeletal and cardiac 
      muscle contraction include eight sarcomeric myosin heavy chain (MyHC) isoforms.
      Six skeletal MyHCs are encoded by genes found in tightly linked clusters on human
      and mouse chromosomes 17 and 11, respectively. The full coding regions of only
      two out of six mammalian skeletal MyHCs had been sequenced prior to this work. In
      an effort to assess the extent of sequence diversity within the human MyHC family
      we present new full-length coding sequences corresponding to four additional
      human genes: MyHC-IIb, MyHC-extraocular, MyHC-IIa and MyHC-IIx/d. This represents
      the first opportunity to compare the full coding sequences of all eight
      sarcomeric MyHC isoforms within a vertebrate organism. Sequence variability has
      been analyzed in the context of available structure/function data with an
      emphasis on potential functional diversity within the family. Results indicate
      that functional diversity among MyHCs is likely to be accomplished by having
      small pockets of sequence diversity in an otherwise highly conserved molecule.
CI  - Copyright 1999 Academic Press.
FAU - Weiss, A
AU  - Weiss A
AD  - Department of Microbiology and Immunology, Albert Einstein College of Medicine,
      1300 Morris Park Avenue, Bronx, 10461, USA.
FAU - Schiaffino, S
AU  - Schiaffino S
FAU - Leinwand, L A
AU  - Leinwand LA
LA  - eng
SI  - GENBANK/AF111782
SI  - GENBANK/AF111783
SI  - GENBANK/AF111784
SI  - GENBANK/AF111785
GR  - GM29090/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Mol Biol
JT  - Journal of molecular biology
JID - 2985088R
RN  - 0 (DNA, Complementary)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Myosin Heavy Chains/*chemistry/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sarcomeres/*chemistry
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/07/02 00:00
MHDA- 1999/07/02 00:01
CRDT- 1999/07/02 00:00
PHST- 1999/07/02 00:00 [pubmed]
PHST- 1999/07/02 00:01 [medline]
PHST- 1999/07/02 00:00 [entrez]
AID - 10.1006/jmbi.1999.2865 [doi]
AID - S0022-2836(99)92865-6 [pii]
PST - ppublish
SO  - J Mol Biol. 1999 Jul 2;290(1):61-75. doi: 10.1006/jmbi.1999.2865.