PMID- 10386598
OWN - NLM
STAT- MEDLINE
DCOM- 19990712
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 452
IP  - 3
DP  - 1999 Jun 11
TI  - Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human
      and mouse; molecular cloning, characterization and tissue distribution of human
      Fuc-TIX.
PG  - 237-42
AB  - The amino acid sequence of Fuc-TIX is very highly conserved between mouse and
      human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene 
      between human and mouse was strikingly low, and almost equivalent to that of the 
      alpha-actin gene. This indicates that Fuc-TIX is under a strong selective
      pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a 
      unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas
      hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts
      were abundantly expressed in brain and stomach, and interestingly were detected
      in spleen and peripheral blood leukocytes.
FAU - Kaneko, M
AU  - Kaneko M
AD  - Division of Cell Biology, Institute of Life Science, Soka University, Tokyo,
      Japan.
FAU - Kudo, T
AU  - Kudo T
FAU - Iwasaki, H
AU  - Iwasaki H
FAU - Ikehara, Y
AU  - Ikehara Y
FAU - Nishihara, S
AU  - Nishihara S
FAU - Nakagawa, S
AU  - Nakagawa S
FAU - Sasaki, K
AU  - Sasaki K
FAU - Shiina, T
AU  - Shiina T
FAU - Inoko, H
AU  - Inoko H
FAU - Saitou, N
AU  - Saitou N
FAU - Narimatsu, H
AU  - Narimatsu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - EC 2.4.1.- (Fucosyltransferases)
RN  - EC 2.4.1.152 (galactoside 3-fucosyltransferase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Conserved Sequence
MH  - Fucosyltransferases/analysis/chemistry/*genetics
MH  - Gastric Mucosa/cytology/*enzymology
MH  - Gene Library
MH  - Genetic Variation
MH  - Humans
MH  - Immunohistochemistry
MH  - Mice
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Phylogeny
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription, Genetic
EDAT- 1999/07/01 00:00
MHDA- 1999/07/01 00:01
CRDT- 1999/07/01 00:00
PHST- 1999/07/01 00:00 [pubmed]
PHST- 1999/07/01 00:01 [medline]
PHST- 1999/07/01 00:00 [entrez]
AID - S0014579399006407 [pii]
AID - 10.1016/s0014-5793(99)00640-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jun 11;452(3):237-42. doi: 10.1016/s0014-5793(99)00640-7.