PMID- 10386589
OWN - NLM
STAT- MEDLINE
DCOM- 19990712
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 452
IP  - 3
DP  - 1999 Jun 11
TI  - Fibrillin degradation by matrix metalloproteinases: identification of amino- and 
      carboxy-terminal cleavage sites.
PG  - 195-8
AB  - Fibrillin molecules form the structural framework of elastic fibrillin-rich
      microfibrils of the extracellular matrix. We have investigated the proteolysis of
      recombinant fibrillin molecules by five matrix metalloproteinases. Cleavage sites
      were defined at the carboxy-terminal end of the fibrillin-1 proline-rich region
      and the corresponding fibrillin-2 glycine-rich region (exon 10), and within exon 
      49 towards the carboxy-terminus of fibrillin-1. Cleavage at these sites is
      predicted to disrupt the structure and function of the fibrillin-rich
      microfibrils.
FAU - Hindson, V J
AU  - Hindson VJ
AD  - Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences,
      University of Manchester, UK.
FAU - Ashworth, J L
AU  - Ashworth JL
FAU - Rock, M J
AU  - Rock MJ
FAU - Cunliffe, S
AU  - Cunliffe S
FAU - Shuttleworth, C A
AU  - Shuttleworth CA
FAU - Kielty, C M
AU  - Kielty CM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Fibrillins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - COS Cells
MH  - Calcium-Binding Proteins/chemistry/metabolism
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Extracellular Matrix Proteins/chemistry/metabolism
MH  - Fibrillins
MH  - Metalloendopeptidases/*metabolism
MH  - Microfilament Proteins/*chemistry/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Peptide Fragments/chemistry/metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Transcription, Genetic
MH  - Transfection
EDAT- 1999/07/01 00:00
MHDA- 1999/07/01 00:01
CRDT- 1999/07/01 00:00
PHST- 1999/07/01 00:00 [pubmed]
PHST- 1999/07/01 00:01 [medline]
PHST- 1999/07/01 00:00 [entrez]
AID - S0014-5793(99)00623-7 [pii]
AID - 10.1016/s0014-5793(99)00623-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jun 11;452(3):195-8. doi: 10.1016/s0014-5793(99)00623-7.