PMID- 10384126
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20190828
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 163
IP  - 1
DP  - 1999 Jul 1
TI  - Genes encoding three new members of the leukocyte antigen 6 superfamily and a
      novel member of Ig superfamily, together with genes encoding the regulatory
      nuclear chloride ion channel protein (hRNCC) and an N omega-N
      omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb
      segment of the MHC class III region.
PG  - 278-87
AB  - Many of the genes in the class III region of the human MHC encode proteins
      involved in the immune and inflammatory responses. We have sequenced a 30-kb
      segment of the MHC class III region lying between the heat shock protein 70 and
      TNF genes as part of a program aimed at identifying genes that could be involved 
      in autoimmune disease susceptibility. The sequence analysis has revealed the
      localization of seven genes, whose precise position and order is
      cen-G7-G6-G6A-G6B-G6C-G6D-G6E-tel, five of which are fully encoded in the
      sequence, allowing their genomic structures to be defined. Three of them (G6C,
      G6D, and G6E) encode putative proteins that belong to the Ly-6 superfamily, known
      to be GPI-anchored proteins attached to the cell surface. Members of the family
      are specifically expressed and are important in leukocyte maturation. A fourth
      gene, G6B, encodes a novel member of the Ig superfamily containing a single Ig
      V-like domain and a cytoplasmic tail with several signal transduction features.
      The G6 gene encodes a regulatory nuclear chloride ion channel protein, while the 
      G6A gene encodes a putative homologue of the enzyme N omega,N
      omega-dimethylarginine dimethylaminohydrolase, which is thought to be involved in
      regulating nitric oxide synthesis. In addition, three microsatellite markers,
      9N-1, 82-2, and D6S273 are contained within the sequence, the last two of which
      have been reported to be strongly associated with the autoimmune disease
      ankylosing spondylitis.
FAU - Ribas, G
AU  - Ribas G
AD  - Medical Research Council Immunochemistry Unit, Department of Biochemistry, Oxford
      University, United Kingdom.
FAU - Neville, M
AU  - Neville M
FAU - Wixon, J L
AU  - Wixon JL
FAU - Cheng, J
AU  - Cheng J
FAU - Campbell, R D
AU  - Campbell RD
LA  - eng
SI  - GENBANK/AJ012008
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Ly)
RN  - 0 (CLIC1 protein, human)
RN  - 0 (Chloride Channels)
RN  - 0 (Clic1 protein, mouse)
RN  - 0 (Genetic Markers)
RN  - 0 (MPIG6B protein, human)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Immunologic)
RN  - EC 3.- (Hydrolases)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.3.18 (dimethylargininase)
SB  - AIM
SB  - IM
MH  - *Amidohydrolases
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, Ly/chemistry/*genetics/isolation & purification
MH  - Chloride Channels/chemistry/*genetics/isolation & purification
MH  - *Genes, Immunoglobulin
MH  - Genetic Markers
MH  - Humans
MH  - Hydrolases/chemistry/*genetics/isolation & purification
MH  - Major Histocompatibility Complex/*genetics
MH  - Mice
MH  - Microsatellite Repeats/immunology
MH  - Molecular Sequence Data
MH  - Multigene Family/*immunology
MH  - Protein Isoforms/chemistry/genetics/isolation & purification
MH  - Receptors, Immunologic/chemistry/*genetics/isolation & purification
MH  - Sequence Alignment
MH  - *Sequence Homology, Amino Acid
MH  - Spondylitis, Ankylosing/genetics/immunology
EDAT- 1999/06/29 00:00
MHDA- 1999/06/29 00:01
CRDT- 1999/06/29 00:00
PHST- 1999/06/29 00:00 [pubmed]
PHST- 1999/06/29 00:01 [medline]
PHST- 1999/06/29 00:00 [entrez]
AID - ji_v163n1p278 [pii]
PST - ppublish
SO  - J Immunol. 1999 Jul 1;163(1):278-87.