PMID- 10383933
OWN - NLM
STAT- MEDLINE
DCOM- 19990917
LR  - 20190513
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 11
IP  - 7
DP  - 1999 Jul
TI  - Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal
      thymus components: distinct ligand-receptor interactions in intrathymic T cell
      development.
PG  - 1017-25
AB  - The suggested role of Notch1 or its mutants in thymocyte differentiation and T
      cell tumorigenesis raises the question of how the different members of the Notch 
      family influence distinct steps in T cell development and the role played by
      Notch ligands in the thymus. We report here that different Notch receptor-ligand 
      partnerships may occur inside the thymus, as we observed differential expression 
      of Notch1, 2 and 3 receptors, their ligands Jagged1 and 2, and downstream
      intracellular effectors hairy and Enhancer of Split homolog 1 (HES-1) and hairy
      and Enhancer of Split homolog 5 (HES-5), depending on ontogenetic stage and
      thymic cell populations. Indeed, while Jagged2 is expressed in both stromal cells
      and thymocytes, Jagged1 expression is restricted to stromal cells. Moreover, a
      differential distribution of Notch3, with respect to Notch1, was observed in
      distinct age-related thymocyte subsets. Finally, Notch3 was preferentially
      up-regulated in thymocytes, following the induction of their differentiation by
      interaction with thymic epithelial cells expressing the cognate Jagged1 and 2
      ligands, suggesting that, besides Notch1, Notch3 may also be involved in distinct
      steps of thymocyte development. Our results suggest that the Notch signaling
      pathway is involved in a complex interplay of T cell developmental stages, as a
      consequence of the heterogeneity and specific expression of members of the Notch 
      receptor family and their cognate ligands, in distinct thymic cell compartments.
FAU - Felli, M P
AU  - Felli MP
AD  - Department of Experimental Medicine, University of L'Aquila, Aquila 67100, Italy.
FAU - Maroder, M
AU  - Maroder M
FAU - Mitsiadis, T A
AU  - Mitsiadis TA
FAU - Campese, A F
AU  - Campese AF
FAU - Bellavia, D
AU  - Bellavia D
FAU - Vacca, A
AU  - Vacca A
FAU - Mann, R S
AU  - Mann RS
FAU - Frati, L
AU  - Frati L
FAU - Lendahl, U
AU  - Lendahl U
FAU - Gulino, A
AU  - Gulino A
FAU - Screpanti, I
AU  - Screpanti I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hes1 protein, mouse)
RN  - 0 (Hes5 protein, mouse)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (JAG1 protein, human)
RN  - 0 (JAG2 protein, human)
RN  - 0 (Jag1 protein, mouse)
RN  - 0 (Jag2 protein, mouse)
RN  - 0 (Jagged-1 Protein)
RN  - 0 (Jagged-2 Protein)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (Notch1 protein, mouse)
RN  - 0 (Notch2 protein, mouse)
RN  - 0 (Notch3 protein, mouse)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Notch1)
RN  - 0 (Receptor, Notch2)
RN  - 0 (Receptor, Notch3)
RN  - 0 (Receptor, Notch4)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Notch)
RN  - 0 (Repressor Proteins)
RN  - 0 (Serrate-Jagged Proteins)
RN  - 0 (Transcription Factor HES-1)
RN  - 0 (Transcription Factors)
RN  - 146991-60-8 (Notch4 protein, mouse)
RN  - 148591-48-4 (HES5 protein, human)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Calcium-Binding Proteins
MH  - Carrier Proteins/biosynthesis/metabolism/*physiology
MH  - Cell Differentiation/immunology
MH  - DNA-Binding Proteins/biosynthesis
MH  - Helix-Loop-Helix Motifs
MH  - Homeodomain Proteins/biosynthesis
MH  - Intercellular Signaling Peptides and Proteins
MH  - Jagged-1 Protein
MH  - Jagged-2 Protein
MH  - Ligands
MH  - Lymphoid Tissue/cytology/metabolism
MH  - Male
MH  - Membrane Proteins/biosynthesis/metabolism/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Protein Biosynthesis
MH  - Proteins/metabolism/*physiology
MH  - Proto-Oncogene Proteins/biosynthesis/metabolism/physiology
MH  - RNA, Messenger/biosynthesis/metabolism
MH  - Receptor, Notch1
MH  - Receptor, Notch2
MH  - Receptor, Notch3
MH  - Receptor, Notch4
MH  - Receptors, Cell Surface/biosynthesis/metabolism/*physiology
MH  - Receptors, Notch
MH  - Repressor Proteins/biosynthesis
MH  - Serrate-Jagged Proteins
MH  - Signal Transduction/immunology
MH  - Stromal Cells/metabolism
MH  - T-Lymphocyte Subsets/cytology
MH  - T-Lymphocytes/*cytology/metabolism
MH  - Thymus Gland/*cytology/*metabolism
MH  - Transcription Factor HES-1
MH  - *Transcription Factors
EDAT- 1999/06/29 00:00
MHDA- 1999/06/29 00:01
CRDT- 1999/06/29 00:00
PHST- 1999/06/29 00:00 [pubmed]
PHST- 1999/06/29 00:01 [medline]
PHST- 1999/06/29 00:00 [entrez]
AID - 10.1093/intimm/11.7.1017 [doi]
PST - ppublish
SO  - Int Immunol. 1999 Jul;11(7):1017-25. doi: 10.1093/intimm/11.7.1017.