PMID- 10383464
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20211203
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 27
DP  - 1999 Jul 2
TI  - Arcadlin is a neural activity-regulated cadherin involved in long term
      potentiation.
PG  - 19473-1979
AB  - Neural activity results in long term changes that underlie synaptic plasticity.
      To examine the molecular basis of activity-dependent plasticity, we have used
      differential cloning techniques to identify genes that are rapidly induced in
      brain neurons by synaptic activity. Here, we identify a novel cadherin molecule
      Arcadlin (activity-regulated cadherin-like protein). arcadlin mRNA is rapidly and
      transiently induced in hippocampal granule cells by seizures and by
      N-methyl-D-aspartate-dependent synaptic activity in long term potentiation. The
      extracellular domain of Arcadlin is most homologous to protocadherin-8; however, 
      the cytoplasmic region is distinct from that of any cadherin family member.
      Arcadlin protein is expressed at the synapses and shows a homophilic binding
      activity in a Ca2+-dependent manner. Furthermore, application of Arcadlin
      antibody reduces excitatory postsynaptic potential amplitude and blocks long term
      potentiation in hippocampal slices. Its close homology with cadherins, its rapid 
      inducibility by neural activity, and its involvement in synaptic transmission
      suggest that Arcadlin may play an important role in activity-induced synaptic
      reorganization underlying long term memory.
FAU - Yamagata, K
AU  - Yamagata K
AD  - Department of Molecular Neurobiology, Tokyo Metropolitan Institute for
      Neuroscience, Fuchu 183, Japan. kyamagat@tmin.ac.jp
FAU - Andreasson, K I
AU  - Andreasson KI
FAU - Sugiura, H
AU  - Sugiura H
FAU - Maru, E
AU  - Maru E
FAU - Dominique, M
AU  - Dominique M
FAU - Irie, Y
AU  - Irie Y
FAU - Miki, N
AU  - Miki N
FAU - Hayashi, Y
AU  - Hayashi Y
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Kaneko, K
AU  - Kaneko K
FAU - Kato, H
AU  - Kato H
FAU - Worley, P F
AU  - Worley PF
LA  - eng
SI  - GENBANK/AB026154
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Antibodies)
RN  - 0 (Cadherins)
RN  - 0 (Pcdh8 protein, rat)
RN  - 0 (Protocadherins)
RN  - 0 (RNA, Messenger)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Base Sequence
MH  - Cadherins/immunology/*physiology
MH  - Calcium/metabolism
MH  - Electrophysiology
MH  - Hippocampus/physiology
MH  - In Situ Hybridization
MH  - L Cells
MH  - *Long-Term Potentiation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protocadherins
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - *Synaptic Transmission
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 10.1074/jbc.274.27.19473 [doi]
AID - S0021-9258(19)74176-3 [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Jul 2;274(27):19473-1979. doi: 10.1074/jbc.274.27.19473.