PMID- 10383454
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 27
DP  - 1999 Jul 2
TI  - IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase
      (IRAK) family.
PG  - 19403-10
AB  - The interleukin-1 receptor-associated kinase (IRAK) was first described as a
      signal transducer for interleukin-1 (IL-1) and has later been implicated in
      signal transduction of other members of the Toll/IL-1 receptor family. We now
      report the identification and characterization of a novel IRAK-like molecule. In 
      contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like
      molecule is found mainly in cells of monomyeloic origin and is, therefore,
      designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a negligible
      autophosphorylation activity, they can reconstitute the IL-1 response in a 293
      mutant cell line lacking IRAK. In addition, we show for the first time that
      members of the IRAK family are indispensable elements of lipopolysaccharide
      signal transduction. The discovery of IRAK-M adds another level of complexity to 
      our understanding of signaling by members of the Toll/IL-1 receptor family.
FAU - Wesche, H
AU  - Wesche H
AD  - Tularik Inc., South San Francisco, California 94080, USA.
FAU - Gao, X
AU  - Gao X
FAU - Li, X
AU  - Li X
FAU - Kirschning, C J
AU  - Kirschning CJ
FAU - Stark, G R
AU  - Stark GR
FAU - Cao, Z
AU  - Cao Z
LA  - eng
SI  - GENBANK/AF113136
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Drosophila Proteins)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (pll protein, Drosophila)
RN  - EC 2.7.11.1 (IRAK3 protein, human)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Antigens, Differentiation/metabolism
MH  - *Drosophila Proteins
MH  - Gene Library
MH  - Humans
MH  - Interleukin-1 Receptor-Associated Kinases
MH  - Molecular Sequence Data
MH  - Myeloid Differentiation Factor 88
MH  - NF-kappa B/metabolism
MH  - Protein Kinases/chemistry/isolation & purification/*metabolism
MH  - Protein-Serine-Threonine Kinases/chemistry
MH  - Proteins/metabolism
MH  - *Receptors, Immunologic
MH  - Receptors, Interleukin-1/*metabolism
MH  - Sequence Alignment
MH  - *Signal Transduction
MH  - TNF Receptor-Associated Factor 6
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 10.1074/jbc.274.27.19403 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jul 2;274(27):19403-10. doi: 10.1074/jbc.274.27.19403.