PMID- 10383417
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 27
DP  - 1999 Jul 2
TI  - Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular 
      signal transduction mediated by cytokines.
PG  - 19129-35
AB  - STAM containing an SH3 (Src homology 3) domain and an immunoreceptor
      tyrosine-based activation motif was previously revealed to be implicated in
      signaling pathways immediately downstream of Jak2 and Jak3 tyrosine kinases
      associated with cytokine receptors. We molecularly cloned a novel molecule
      interacting with the SH3 domain of STAM, which was named AMSH (associated
      molecule with the SH3 domain of STAM). AMSH contains a putative bipartite nuclear
      localization signal and a homologous region of a c-Jun activation domain-binding 
      protein 1 (JAB1) subdomain in addition to a binding site for the SH3 domain of
      STAM. AMSH mutant deleted of the C-terminal half conferred dominant negative
      effects on signaling for DNA synthesis and c-myc induction mediated by
      interleukin 2 and granulocyte macrophage-colony-stimulating factor. These results
      suggest that AMSH plays a critical role in the cytokine-mediated intracellular
      signal transduction downstream of the Jak2/Jak3.STAM complex.
FAU - Tanaka, N
AU  - Tanaka N
AD  - Department of Microbiology and Immunology, Tohoku University School of Medicine, 
      2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Kaneko, K
AU  - Kaneko K
FAU - Asao, H
AU  - Asao H
FAU - Kasai, H
AU  - Kasai H
FAU - Endo, Y
AU  - Endo Y
FAU - Fujita, T
AU  - Fujita T
FAU - Takeshita, T
AU  - Takeshita T
FAU - Sugamura, K
AU  - Sugamura K
LA  - eng
SI  - GENBANK/U73522
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
RN  - 0 (Interleukin-2)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (STAM protein, human)
RN  - 0 (Transcription Factors)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.-.- (COPS5 protein, human)
RN  - EC 3.4.19.12 (COP9 Signalosome Complex)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - COP9 Signalosome Complex
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cloning, Molecular
MH  - Consensus Sequence
MH  - DNA Replication
MH  - DNA-Binding Proteins/metabolism
MH  - Endosomal Sorting Complexes Required for Transport
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - Interleukin-2/metabolism
MH  - Intracellular Signaling Peptides and Proteins
MH  - JNK Mitogen-Activated Protein Kinases
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Peptide Hydrolases
MH  - Phosphoproteins/*metabolism
MH  - Proto-Oncogene Proteins c-myc/metabolism
MH  - *Signal Transduction
MH  - Transcription Factors/metabolism
MH  - *src Homology Domains
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 10.1074/jbc.274.27.19129 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jul 2;274(27):19129-35. doi: 10.1074/jbc.274.27.19129.