PMID- 10383128
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 12
DP  - 1999 Jun 15
TI  - Molecular cloning and functional analysis of the mouse homologue of the
      KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death 
      receptor.
PG  - 2770-5
AB  - Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors
      are members of the tumor necrosis factor superfamily. TRAIL selectively kills
      cancer cells but not normal cells. We report here the cloning of the mouse
      homologue of the TRAIL receptor KILLER/DR5 (MK). The cDNA of MK is 1146 bp in
      length and encodes a protein of 381 amino acids. MK contains an extracellular
      cysteine-rich domain, a transmembrane domain, and a cytoplasmic death-domain
      characteristic of Fas, tumor necrosis factor, and human TRAIL receptors. MK is
      highly homologous and binds TRAIL with similar affinity as human DR4 and
      KILLER/DR5. MK induces apoptosis in mouse and human cells and inhibits colony
      growth of NIH3T3 cells. Expression of MK is p53-dependent and up-regulated by
      tumor suppressor p53 and by DNA damaging agents in mouse cells undergoing
      apoptosis. This is the first report describing a mouse TRAIL receptor gene and
      also demonstrating that the p53-dependent regulation of KILLER/DR5-mediated
      apoptosis is conserved between human and mouse.
FAU - Wu, G S
AU  - Wu GS
AD  - Howard Hughes Medical Institute, Department of Medicine, and Cancer Center,
      University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.
FAU - Burns, T F
AU  - Burns TF
FAU - Zhan, Y
AU  - Zhan Y
FAU - Alnemri, E S
AU  - Alnemri ES
FAU - El-Deiry, W S
AU  - El-Deiry WS
LA  - eng
SI  - GENBANK/AF176833
GR  - AG14357/AG/NIA NIH HHS/United States
GR  - CA75138-01/CA/NCI NIH HHS/United States
GR  - CA75454-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNFRSF10B protein, human)
RN  - 0 (TNFSF10 protein, human)
RN  - 0 (Tnfrsf10b protein, mouse)
RN  - 0 (Tnfsf10 protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis/genetics
MH  - Apoptosis Regulatory Proteins
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Colony-Forming Units Assay
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Membrane Glycoproteins/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand
MH  - Receptors, Tumor Necrosis Factor/*genetics/physiology
MH  - Sequence Homology, Amino Acid
MH  - TNF-Related Apoptosis-Inducing Ligand
MH  - Tumor Cells, Cultured
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Tumor Suppressor Protein p53/physiology
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Jun 15;59(12):2770-5.