PMID- 10382972
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190816
IS  - 1340-2838 (Print)
IS  - 1340-2838 (Linking)
VI  - 6
IP  - 2
DP  - 1999 Apr 30
TI  - Genomic organization and chromosomal localization of the human cathepsin L2 gene.
PG  - 137-40
AB  - Cathepsin L2 is a recently described cysteine proteinase with high sequence
      homology to cathepsin L and other members of the papain superfamily of cysteine
      proteinases. Its expression is regulated in a tissue-specific manner and is high 
      in thymus, testis and cornea. In the present study, the entire gene sequence,
      including 5' and 3' flanking region, and chromosomal localization of human
      cathepsin L2 were determined. The gene spans approximately 6.4 kb and consists of
      eight exons and seven introns. Genomic organization was similar to human
      cathepsin L and more than 50% similarity was found between the first introns of
      cathepsin L and L2, suggesting that they diverged late in evolution. The
      transcription initiation site, determined by primer extension, was 198
      nucleotides from the first ATG. The 5' flanking region lacks a TATA box but has
      one SP1 site. The gene was mapped to chromosome 9q21-22 by fluorescence in situ
      hybridization and the distance from cathepsin L was determined to be 15 cM by
      compiling radiation hybrid mapping results with a genetic map.
FAU - Itoh, R
AU  - Itoh R
AD  - Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan.
FAU - Kawamoto, S
AU  - Kawamoto S
FAU - Adachi, W
AU  - Adachi W
FAU - Kinoshita, S
AU  - Kinoshita S
FAU - Okubo, K
AU  - Okubo K
LA  - eng
SI  - GENBANK/AB019534
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - DNA Res
JT  - DNA research : an international journal for rapid publication of reports on genes
      and genomes
JID - 9423827
RN  - 0 (DNA, Complementary)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.43 (CTSV protein, human)
SB  - IM
MH  - Base Sequence
MH  - Cathepsins/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 9
MH  - Cysteine Endopeptidases/*genetics
MH  - DNA, Complementary
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - RNA Splicing
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 10.1093/dnares/6.2.137 [doi]
PST - ppublish
SO  - DNA Res. 1999 Apr 30;6(2):137-40. doi: 10.1093/dnares/6.2.137.