PMID- 10382763
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20180424
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 29
IP  - 6
DP  - 1999 Jun
TI  - NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic
      granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome
      1.
PG  - 2000-6
AB  - Several receptors expressed by subsets of leukocytes and with sequence homology
      to the killer cell inhibitory receptors have recently been identified both in man
      and mouse. Here we describe a rat cDNA that encodes a novel receptor of this
      group, designated neutrophil immunoglobulin-like receptor-1 (NILR-1). The
      predicted 58.7-kDa mature NILR-1 protein is a type I integral membrane protein,
      with three C2-type immunoglobulin superfamily domains, a transmembrane region
      devoid of charged amino acids, and a cytoplasmic tail containing four
      immunoreceptor tyrosine-based inhibition motif-like regions. NILR-1 shows
      greatest sequence homology to the mouse paired immunoglobulin-like receptor-B and
      members of the human leukocyte immunoglobulin-like receptor/immunoglobulin-like
      transcript group of receptors. As shown by Northern blot analysis, NILR-1 was
      transcribed by neutrophilic granulocytes. Although weaker transcription was found
      with a macrophage cell line, no signal was detected with peritoneal macrophage or
      spleen RNA. Linkage analysis localized Nilr1 to chromosome 1, closely linked to a
      locus encoding a rat NKp46 orthologue. The two loci define a rat leukocyte
      receptor gene complex, in a region syntenic to human chromosome 19q13.4 and the
      proximal part of mouse chromosome 7, that harbors the human and mouse leukocyte
      receptor gene complexes.
FAU - Berg, S F
AU  - Berg SF
AD  - Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo,
      Norway. s.f.berg@basalmed.uio.no
FAU - Fossum, S
AU  - Fossum S
FAU - Dissen, E
AU  - Dissen E
LA  - eng
SI  - GENBANK/AF082534
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (DNA, Complementary)
RN  - 0 (Immunoglobulins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (neutrophil immunoglobulin-like receptor 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Gene Expression
MH  - Humans
MH  - Immunoglobulins/*genetics
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neutrophils/*immunology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Immunologic/chemistry/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Tissue Distribution
EDAT- 1999/06/26 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/06/26 10:00
PHST- 1999/06/26 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/06/26 10:00 [entrez]
AID - 10.1002/(SICI)1521-4141(199906)29:06<2000::AID-IMMU2000>3.0.CO;2-5 [doi]
PST - ppublish
SO  - Eur J Immunol. 1999 Jun;29(6):2000-6. doi:
      10.1002/(SICI)1521-4141(199906)29:06<2000::AID-IMMU2000>3.0.CO;2-5.